ArticleJournal of the American Chemical Society2010
Paramagnetic, silicon quantum dots for magnetic resonance and two-photon imaging of macrophages.
Article in Journal of the American Chemical Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Illuminating Immunity: A Systematic Review of Immune Cell Autofluorescence.Journal of biophotonics · 2025Pooled it
- Bright Semiconductor Quantum Dots Shed New Light on Precision Nanomedicine for Various Diseases.Small science · 2024Article
- Synthesis of Magnetic Ions-Doped QDs Synthesized Via a Facial Aqueous Solution Method for Optical/MR Dual-Modality Imaging Applications.Journal of fluorescence · 2021Article
- Zintl Phases as Reactive Precursors for Synthesis of Novel Silicon and Germanium-Based Materials.Materials (Basel, Switzerland) · 2019Review
- Review
- MnJournal of functional biomaterials · 2017Article
- Nanometer size silicon particles for hyperpolarized MRI.Scientific reports · 2017Article
- Bright long-lived luminescence of silicon nanocrystals sensitized by two-photon absorbing antenna.Chem · 2017Article
- EPR and Structural Characterization of Water-Soluble MnThe journal of physical chemistry. C, Nanomaterials and interfaces · 2017Article
- Linear and Non-Linear Optical Imaging of Cancer Cells with Silicon Nanoparticles.International journal of molecular sciences · 2016Article
- In vivo inflammation imaging using a CB2R-targeted near infrared fluorescent probe.American journal of nuclear medicine and molecular imaging · 2015Article
- Color Tunable Gd-Zn-Cu-In-S/ZnS Quantum Dots for Dual Modality Magnetic Resonance and Fluorescence Imaging.Nano research · 2014Article
- Multimodality PET/MRI agents targeted to activated macrophages.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2014Article
- In vivo detection of macrophage recruitment in hind-limb ischemia using a targeted near-infrared fluorophore.PloS one · 2014Article
- Synthesis of long T₁ silicon nanoparticles for hyperpolarized ²⁹Si magnetic resonance imaging.ACS nano · 2013Article
- Article
- Silica microparticles as a solid support for gadolinium phosphonate magnetic resonance imaging contrast agents.Journal of the American Chemical Society · 2012Article
- Development of manganese-based nanoparticles as contrast probes for magnetic resonance imaging.Theranostics · 2012Article
- Femtosecond ligand/core dynamics of microwave-assisted synthesized silicon quantum dots in aqueous solution.Journal of the American Chemical Society · 2011Article
- Receptor-targeted iron oxide nanoparticles for molecular MR imaging of inflamed atherosclerotic plaques.Biomaterials · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Quantum dots (QDs) are an attractive platform for building multimodality imaging probes, but the toxicity for typical cadmium QDs limits enthusiasm for their clinical use. Nontoxic, silicon QDs are more promising but tend to require short-wavelength excitations which are subject to tissue scattering and autofluorescence artifacts. Herein, we report the synthesis of paramagnetic, manganese-doped, silicon QDs (Si(Mn) QDs) and demonstrate that they are detectable by both MRI and near-infrared excited, two-photon imaging. The Si(Mn) QDs are coated with dextran sulfate to target them to scavenger receptors on macrophages, a biomarker of vulnerable plaques. TEM images show that isolated QDs have an average core diameter of 4.3 +/- 1.0 nm and the hydrodynamic diameters of coated nanoparticles range from 8.3 to 43 nm measured by dynamic light scattering (DLS). The Si(Mn) QDs have an r(1) relaxivity of 25.50 +/- 1.44 mM(-1) s(-1) and an r(2) relaxivity of 89.01 +/- 3.26 mM(-1) s(-1) (37 degrees C, 1.4 T). They emit strong fluorescence at 441 nm with a quantum yield of 8.1% in water. Cell studies show that the probes specifically accumulate in macrophages by a receptor-mediated process, are nontoxic to mammalian cells, and produce distinct contrast in both T(1)-weighted magnetic resonance and single- or two-photon excitation fluorescence images. These QDs have promising diagnostic potential as high macrophage density is associated with atherosclerotic plaques vulnerable to rupture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.