Evidence map›Paper›PMID 20091874›Full record

ReviewBiopolymers2010

Self-assembly of peptide amphiphiles: from molecules to nanostructures to biomaterials.

Honggang Cui, Matthew J Webber, Samuel I Stupp

Abstract readReview
In one paragraph

Review in Biopolymers, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 415 papers.

0numbers the graph read from it
0cells of the map it votes in
415citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

415 citing papers in PubMed.

  1. Article
  2. Article
  3. Injury and therapy in a human spinal cord organoid.Nature biomedical engineering · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Nanostructure and Collagen-Stimulating Activity of Cationic Pentapeptide Lipopeptides.Journal of peptide science : an official publication of the European Peptide Society · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Self-Assembly of Anti-Inflammatory Peptide Amphiphiles for Mucosal Health.Chembiochem : a European journal of chemical biology · 2026
    Article
  15. Article
  16. Self-Assembling Short Peptide Carriers for Gene Delivery.International journal of molecular sciences · 2026
    Review
  17. Cell-Laden Supramolecular and Covalent Polymer Hydrogels for High-Shear Delivery: A Design of Experiments Approach.Chemistry of materials : a publication of the American Chemical Society · 2026
    Article
  18. Substituent-Based Modulation of Self-Assembly and Immunogenicity of Amphipathic Peptides.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  19. Review
  20. Article

355 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Honggang CuiDepartment of Materials Science and Engineering, Northwestern University, 2220 Campus Drive, Evanston, IL 60208, USA.
Matthew J Webber
Samuel I Stupp

Funding

TiO2 nanocomposites for Targeted Treatment and Imaging of Prostate cancerU54CA119341 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MIRKIN, CHAD A. · 2005 to 2009
$19.9M
Regenerative Scaffold Technologies for CNS and DiabetesR01EB003806 · NIBIB · NORTHWESTERN UNIVERSITY AT CHICAGO · PI STUPP, SAMUEL I · 2004 to 2015
$10.7M
Nanotechnology Strategies for Growth of Bones and TeethR01DE015920 · NIDCR · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SNEAD, MALCOLM L., STUPP, SAMUEL I · 2005 to 2015
$5.8M
Tissue Culture CoreP50NS054287 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KESSLER, JOHN A · 2005 to 2008
$3.6M
Training for a New Interdisciplinary Research Workforce in Regenerative MedicineT90DA022881 · NIDA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KESSLER, JOHN A · 2006 to 2009
$1.1M
NCI NIH HHS 5 U54 CA119341-04NCI NIH HHS U54 CA119341NIBIB NIH HHS 5 R01 EB003806NIBIB NIH HHS R01 EB003806NIDA NIH HHS 5T90-DA022881NIDA NIH HHS T90 DA022881NIDCR NIH HHS 5 R01 DE015920-3NIDCR NIH HHS R01 DE015920NINDS NIH HHS 5 P50 NS054287-04NINDS NIH HHS P50 NS054287
6 · The paper itself

Abstract

Peptide amphiphiles are a class of molecules that combine the structural features of amphiphilic surfactants with the functions of bioactive peptides and are known to assemble into a variety of nanostructures. A specific type of peptide amphiphiles are known to self-assemble into one-dimensional nanostructures under physiological conditions, predominantly nanofibers with a cylindrical geometry. The resultant nanostructures could be highly bioactive and are of great interest in many biomedical applications, including tissue engineering, regenerative medicine, and drug delivery. In this context, we highlight our strategies for using molecular self-assembly as a toolbox to produce peptide amphiphile nanostructures and materials and efforts to translate this technology into applications as therapeutics. We also review our recent progress in using these materials for treating spinal cord injury, inducing angiogenesis, and for hard tissue regeneration and replacement.

Indexed as

Biocompatible MaterialsNanostructuresProtein ConformationCross-Linking ReagentsHumansLightMagnetic Resonance ImagingModels, MolecularMolecular StructureNeovascularization, PhysiologicNeuronsPeptidesRegenerationSurface-Active AgentsSurface PropertiesBiocompatible MaterialsCross-Linking ReagentsPeptidesSurface-Active Agents

Identifiers

PMID20091874
PMCPMC2921868

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.