SynthesisThe Cochrane database of systematic reviews2010
Blood transfusions for treating acute chest syndrome in people with sickle cell disease.
Synthesis in The Cochrane database of systematic reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 5 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- American Society of Hematology 2020 guidelines for sickle cell disease: transfusion support.Blood advances · 2020Guideline
- Blood transfusions for treating acute chest syndrome in people with sickle cell disease.The Cochrane database of systematic reviews · 2020Pooled it
- Regular long-term red blood cell transfusions for managing chronic chest complications in sickle cell disease.The Cochrane database of systematic reviews · 2019Pooled it
- Red blood cell transfusion to treat or prevent complications in sickle cell disease: an overview of Cochrane reviews.The Cochrane database of systematic reviews · 2018Pooled it
- Regular long-term red blood cell transfusions for managing chronic chest complications in sickle cell disease.The Cochrane database of systematic reviews · 2016Pooled it
- Incidence of sickle cell disease patients with pulmonary embolism admitted to the intensive care unit in Bahrain.Saudi medical journal · 2020Article
- Red blood cell transfusion to treat or prevent complications in sickle cell disease: an overview of Cochrane reviews.The Cochrane database of systematic reviews · 2016Article
- Treatment for sickle cell disease in Africa: should we invest in haematopoietic stem cell transplantation?The Pan African medical journal · 2014Article
- Pulmonary complications of sickle cell disease.American journal of respiratory and critical care medicine · 2012Review
- Adult Sickle Cell Disease: A Five-year Experience of Intensive Care Management in a University Hospital in Oman.Sultan Qaboos University medical journal · 2012Article
- Beyond the definitions of the phenotypic complications of sickle cell disease: an update on management.TheScientificWorldJournal · 2012Review
- The impact of the 2009 H1N1 influenza pandemic on pediatric patients with sickle cell disease.Pediatric blood & cancer · 2011Article
Corrections and comments
- Updated by
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSickle cell disease (SCD) is an inherited autosomal recessive blood condition and is one of the most prevalent genetic blood diseases worldwide. Acute chest syndrome (ACS) is a frequent complication of sickle cell disease, as well as a major cause of morbidity and the greatest single cause of mortality in children with SCD. Standard treatment may include intravenous hydration, oxygen as treatment for hypoxia, antibiotics to treat the infectious cause and blood transfusions may be given.
objectivesTo assess the effectiveness of blood transfusions, simple and exchange, for treating ACS by comparing improvement in symptoms and clinical outcomes against standard care. SEARCH STRATEGY: We searched The Group's Haemoglobinopathies Trials Register, which comprises references identified from comprehensive electronic database searches and handsearching of relevant journals and abstract books of conference proceedings.Most recent search: 27 March 2009. SELECTION CRITERIA: Randomised controlled trials and quasi-randomised controlled trials comparing either simple or exchange transfusion versus standard care (no transfusion) in people with sickle cell disease suffering from acute chest syndrome. DATA COLLECTION AND ANALYSIS: No studies were identified for inclusion in the review. MAIN
resultsNo studies were identified for inclusion in the review. AUTHORS'
conclusionsThere is currently no reliable evidence to support or refute the effectiveness of blood transfusions as treatment options for acute chest syndrome in people with sickle cell disease. Well-designed, adequately-powered randomised controlled trials are now required to assess the benefits and risks of this form of treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.