SynthesisThe Cochrane database of systematic reviews2010
Vitamin D for the treatment of chronic painful conditions in adults.
Synthesis in The Cochrane database of systematic reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Vitamin D for the treatment of chronic painful conditions in adults.The Cochrane database of systematic reviews · 2015Pooled it
- High dose vitamin D therapy for chronic pain in children and adolescents with sickle cell disease: results of a randomized double blind pilot study.British journal of haematology · 2012Trial
- Vitamin D supplementation for nonspecific musculoskeletal pain in non-Western immigrants: a randomized controlled trial.Annals of family medicineTrial
- Vitamin D, chronic pain, and depression: linear and non-linear Mendelian randomization analyses.Translational psychiatry · 2024Article
- Nutrient insufficiencies and deficiencies involved in the pathogenesis of bruxism (Review).Experimental and therapeutic medicine · 2023Review
- Prevalence, risk factor and outcome in middle-aged and elderly population affected by hemiplegic shoulder pain: An observational study.Frontiers in neurology · 2022Article
- Chronic pain: a review of its epidemiology and associated factors in population-based studies.British journal of anaesthesia · 2019Review
- Vitamin D testing: finding a balance.Clinical rheumatology · 2018Article
- Impact of season and different vitamin D thresholds on prevalence of vitamin D deficiency in epidemiological cohorts-a note of caution.Endocrine · 2017Article
- Association of arthritis and vitamin D insufficiency with physical disability in Mexican older adults: findings from the Mexican Health and Aging Study.Rheumatology international · 2017Article
- Serum Vitamin D Status in Iranian Fibromyalgia Patients: according to the Symptom Severity and Illness Invalidation.The Korean journal of pain · 2016Article
- Corneal Dendritic Cell Density Is Associated with Subbasal Nerve Plexus Features, Ocular Surface Disease Index, and Serum Vitamin D in Evaporative Dry Eye Disease.BioMed research international · 2016Article
- Vitamin D Deficiency and Pain: Clinical Evidence of Low Levels of Vitamin D and Supplementation in Chronic Pain States.Pain and therapy · 2015Article
- Significant association among growing pains, vitamin D supplementation, and bone mineral status: results from a pilot cohort study.Journal of bone and mineral metabolism · 2015Article
- Vitamin D and autoimmune thyroid diseases: facts and unresolved questions.Immunologic research · 2015Review
- Impact of vitamin D supplementation on health-care use in a 25-hydroxyvitamin D-tested population in France: a population-based descriptive cohort study.Public health nutrition · 2015Article
- Vitamin D and Pain: Vitamin D and Its Role in the Aetiology and Maintenance of Chronic Pain States and Associated Comorbidities.Pain research and treatment · 2015Review
- Is there a role for vitamin D in the treatment of chronic pain?Inflammopharmacology · 2014Article
- Chronic pain epidemiology - where do lifestyle factors fit in?British journal of pain · 2013Article
- Vitamin D in systemic and organ-specific autoimmune diseases.Clinical reviews in allergy & immunology · 2013Review
Corrections and comments
- Updated by
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVitamin D is produced in the skin after sun-light exposure and can also be obtained through food. Vitamin D deficiency has recently been linked with a range of diseases including chronic pain. Observational and circumstantial evidence suggests that there may be a role for vitamin D deficiency in the aetiology of chronic pain conditions.
objectivesTo assess the efficacy and adverse events of vitamin D supplementation in chronic painful conditions. SEARCH STRATEGY: We searched Cochrane CENTRAL, MEDLINE, EMBASE and the Oxford Pain Relief Database for studies to September 2009. This was supplemented by searching the reference lists of retrieved articles, textbooks and reviews. SELECTION CRITERIA: Studies were included if they were randomised double blind trials of vitamin D supplementation compared with placebo or with active comparators for the treatment of chronic pain conditions in adults. DATA COLLECTION AND ANALYSIS: Two review authors independently selected the studies for inclusion, assessed methodological quality, and extracted data. Pooled analysis was not undertaken due to paucity and heterogeneity of data. MAIN
resultsFour studies, with a total of 294 participants, were included. The studies were heterogeneous with regard to study quality, the chronic painful conditions that were investigated, and the outcome measures reported. Only one study reported a beneficial effect, the others found no benefit of vitamin D over placebo in treating chronic pain. AUTHORS'
conclusionsThe evidence base for the use of vitamin D for chronic pain in adults is poor at present. This is due to low quality and insufficient randomised controlled trials in this area of research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.