SynthesisThe Cochrane database of systematic reviews2010
Surface neuromuscular electrical stimulation for quadriceps strengthening pre and post total knee replacement.
Synthesis in The Cochrane database of systematic reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 5 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Comparison of Therapeutic Effects of Different Rehabilitation Methods on Patients Undergoing Total Knee Arthroplasty: A Network Meta-Analysis of Randomized Controlled Trials.Orthopaedic surgery · 2025Pooled it
- A Comparison of Neuromuscular Electrical Stimulation Parameters for Postoperative Quadriceps Strength in Patients After Knee Surgery: A Systematic Review.Sports health · 2021Pooled it
- Effect of Neuromuscular Electrical Stimulation After Total Knee Arthroplasty: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Frontiers in medicine · 2021Pooled it
- Neuromuscular electrical stimulation (NMES) for patellofemoral pain syndrome.The Cochrane database of systematic reviews · 2017Pooled it
- Femoral quadriceps neuromuscular electrical stimulation after total knee arthroplasty: a systematic review.Einstein (Sao Paulo, Brazil)Pooled it
- The effects of exercise and neuromuscular electrical stimulation in subjects with knee osteoarthritis: a 3-month follow-up study.Clinical interventions in aging · 2014Trial
- Effects of neuromuscular electrical stimulation combined with exercises versus an exercise program on the pain and the function in patients with knee osteoarthritis: a randomized controlled trial.BioMed research international · 2013Trial
- Is neuromuscular electrical stimulation effective for improving pain, function and activities of daily living of knee osteoarthritis patients? A randomized clinical trial.Sao Paulo medical journal = Revista paulista de medicina · 2013Trial
- Relationship between intensity of quadriceps muscle neuromuscular electrical stimulation and strength recovery after total knee arthroplasty.Physical therapy · 2012Trial
- Development, Urdu translation, and validation of a lifestyle modification manual for patients post-total knee replacement.Frontiers in rehabilitation sciences · 2025Article
- Arthralgia: a map of Cochrane evidence relevant to rehabilitation for people with post COVID-19 condition.European journal of physical and rehabilitation medicine · 2022Review
- Does TENS Reduce the Intensity of Acute and Chronic Pain? A Comprehensive Appraisal of the Characteristics and Outcomes of 169 Reviews and 49 Meta-Analyses.Medicina (Kaunas, Lithuania) · 2021Review
- Additional effect of neuromuscular electrical stimulation on knee extension lag, pain and knee range of motion in immediate postsurgical phase (0-2 weeks) in primary total knee arthroplasty patient.Annals of translational medicine · 2019Article
- Content Validation of Total Knee Replacement Rehabilitation Protocol in Indian Population.Journal of clinical and diagnostic research : JCDR · 2017Article
- An evidence-based review of enhanced recovery interventions in knee replacement surgery.Annals of the Royal College of Surgeons of England · 2013Review
- Osteoarthritis: physical medicine and rehabilitation--nonpharmacological management.Wiener medizinische Wochenschrift (1946) · 2013Review
- Peri-operative interventions producing better functional outcomes and enhanced recovery following total hip and knee arthroplasty: an evidence-based review.BMC medicine · 2013Review
- A murine model of muscle training by neuromuscular electrical stimulation.Journal of visualized experiments : JoVE · 2012Article
- A theoretical framework for understanding neuromuscular response to lower extremity joint injury.Sports health · 2012Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTotal knee replacement has been demonstrated to be one of the most successful procedures in the treatment of osteoarthritis. However quadriceps weakness and reductions in function are commonly reported following surgery. Recently Neuromuscular Electrical Stimulation (NMES) has been used as an adjunct to traditional strengthening programmes. This review considers the effectiveness of NMES as a means of increasing quadriceps strength in patients before and after total knee replacement.
objectivesTo assess the effectiveness of NMES as a means of improving quadriceps strength before and after total knee replacement. SEARCH STRATEGY: We searched The Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (1950 to January week 1 2008), EMBASE (1980 to 2008 week 2), Cumulative Index to Nursing and Allied Health Literature (CINAHL)(1982 to 2007/11), AMED (1985 to Jan 2008), Web of Science, and Pedro (Jan 2008) (http://www.pedro.fhs.usyd.edu.au/index.html) for randomised controlled trials and controlled clinical trials. The electronic search was complimented by hand searches and experts in the area and companies supplying NMES equipment were also contacted. SELECTION CRITERIA: Randomised controlled trials and controlled clinical trials were accepted that used NMES for the purpose of quadriceps strengthening either pre or post total knee replacement. DATA COLLECTION AND ANALYSIS: Two review authors decided which studies were suitable for inclusion based on the inclusion and exclusion criteria in the protocol and the data was extracted using pre-developed data extraction forms. Two review authors (BM and BC) independently assessed the methodological quality of the included trials using a descriptive approach as advocated by the Musculoskeletal group. Only two studies were included in the review. Neither study presented results in a form suitable for meta-analysis. The authors of both studies were contacted to obtain the raw data but they were no longer available.The data from both studies are described in the review. MAIN
resultsTwo studies were identified for inclusion in the review. No significant differences were reported in either study for maximum voluntary isometric torque or endurance between the NMES group and the control group but significantly better quadriceps muscle activation was reported in the exercise and neuromuscular stimulation group compared with the exercise group alone in the second study. This difference was significant at the mid training (six week) time point but not at the twelfth week post training time point. Further analysis of both studies were not possible due to the absence of raw data scores. Both studies carried a high risk of bias. Mean values were not given for strength, endurance, cross sectional area or quality of life. Pain outcomes, patient satisfaction or adverse effects were not reported in either study. The results were presented as percentage improvements from baseline and the number of subjects in each group was unclear. AUTHORS'
conclusionsThe studies found in this review do not permit any conclusions to be made about the application of neuromuscular stimulation for the purposes of quadriceps strengthening before or after total knee replacement. At this time the evidence for the use of neuromuscular stimulation for the purposes of quadriceps strengthening in this patient group is unclear.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.