SynthesisThe Cochrane database of systematic reviews2010
Antiepileptic drugs for the primary and secondary prevention of seizures after stroke.
Synthesis in The Cochrane database of systematic reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Antiepileptic drugs for the primary and secondary prevention of seizures after stroke.The Cochrane database of systematic reviews · 2022Pooled it
- Immediate antiepileptic drug treatment, versus placebo, deferred, or no treatment for first unprovoked seizure.The Cochrane database of systematic reviews · 2021Pooled it
- Immediate antiepileptic drug treatment, versus placebo, deferred, or no treatment for first unprovoked seizure.The Cochrane database of systematic reviews · 2016Pooled it
- Predictors of Seizure Recurrence after Acute Symptomatic Seizures in Ischemic Stroke Patients.Neuroscience journal · 2019Article
- The efficacy of gastrodin in combination with folate and vitamin B12 on patients with epilepsy after stroke and its effect on HMGB-1, IL-2 and IL-6 serum levels.Experimental and therapeutic medicine · 2017Article
- Survey of prophylactic antiseizure drug use for non-traumatic intracerebral hemorrhage.Neurological research · 2013Article
- Seven questions about stroke and epilepsy.Epilepsy currents · 2012Article
- Management of seizures following a stroke: what are the options?Drugs & aging · 2012Review
- Symptomatic and palliative care for stroke survivors.Journal of general internal medicine · 2012Review
- Gabapentin: An update of its pharmacological properties and therapeutic use in epilepsy.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2011Article
- Seizure risk from cavernous or arteriovenous malformations: prospective population-based study.Neurology · 2011Article
- Stroke: predicting the risk of poststroke epilepsy-why and how?Nature reviews. Neurology · 2010Article
Corrections and comments
- Updated by
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeizures after stroke are an important clinical problem, and they may be associated with poor outcome. The effects of antiepileptic drugs for the primary and secondary prevention of seizures after stroke remain unclear.
objectivesWe aimed to assess the effects of antiepileptic drugs for the primary and secondary prevention of seizures after stroke. SEARCH STRATEGY: We searched the Specialised Registers of the Cochrane Epilepsy Group and the Cochrane Stroke Group (2 July 2009), the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library Issue 2, 2009), and MEDLINE (1950 to June, week 4, 2009). We also checked the reference lists of articles retrieved from these searches. SELECTION CRITERIA: Randomised and quasi-randomised controlled trials in which patients were assigned to treatment or control group (placebo or no drug). DATA COLLECTION AND ANALYSIS: Both review authors independently screened all the titles, abstracts, and keywords of publications identified by the searches to assess their eligibility, and both review authors assessed their suitability for inclusion according to pre-specified selection criteria. No study was included, hence no data analysis was performed. MAIN
resultsWe did not find any randomised controlled trials that have compared the effects of antiepileptic drugs with placebo (or no drug) for the primary or secondary prevention of seizures after stroke. We did, however, find three randomised controlled trials that have assessed the effects of several different antiepileptic drugs for the secondary prevention of post-stroke seizures. The first study was performed in older adults (mean age 72 years) with a mixture of diagnoses including stroke (comparing carbamazepine, lamotrigine and gabapentin); the second study was performed in children and younger adults (mean age 38 years) with a mixture of diagnoses including stroke (comparing carbamazepine, oxcarbazepine, lamotrigine, gabapentin and topiramate); and the third study was performed in stroke patients only (comparing carbamazepine and lamotrigine). AUTHORS'
conclusionsCurrently, there is insufficient evidence to support the routine use of antiepileptic drugs for the primary or secondary prevention of seizures after stroke. Further well-conducted research is needed for this important clinical problem.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.