Trial reportBehavior genetics2010
Polymorphisms in dopamine transporter (SLC6A3) are associated with stimulant effects of D-amphetamine: an exploratory pharmacogenetic study using healthy volunteers.
Trial report in Behavior genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02634684 (Pharmacologic Augmentation of Neurocognition and Cognitive Training in Psychosis), which is not on this map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pharmacologic Augmentation of Neurocognition and Cognitive Training in Psychosis
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Systematic reviews of the acute effects of amphetamine on working memory and other cognitive performances in healthy individuals, with a focus on the potential influence of personality traits.Human psychopharmacology · 2023Pooled it
- Neurocognitive enhancement or impairment? A systematic meta-analysis of prescription stimulant effects on processing speed, decision-making, planning, and cognitive perseveration.Experimental and clinical psychopharmacology · 2016Pooled it
- The effects of caffeine and d-amphetamine on spatial span task in healthy participants.PloS one · 2023Trial
- COMT polymorphism modulates the resting-state EEG alpha oscillatory response to acute nicotine in male non-smokers.Genes, brain, and behavior · 2015Trial
- Candidate gene studies of a promising intermediate phenotype: failure to replicate.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Trial
- Neurochemical and Genetic Alterations in Chronic Stimulant (Crystal and Captagon) Users: A Comparative Analysis of Monoamine Biomarkers and Addiction-Related Gene Expression.Biochemistry research international · 2026Article
- Review
- Shared Behavioral and Neurocircuitry Disruptions in Drug Addiction, Obesity, and Binge Eating Disorder: Focus on Group I mGluRs in the Mesolimbic Dopamine Pathway.ACS chemical neuroscience · 2019Review
- Amphetamine Enhances Gains in Auditory Discrimination Training in Adult Schizophrenia Patients.Schizophrenia bulletin · 2017Article
- A review of pharmacogenetic studies of substance-related disorders.Drug and alcohol dependence · 2015Review
- Genetic variation of the dopamine transporter (DAT1) influences the acute subjective responses to cocaine in volunteers with cocaine use disorders.Pharmacogenetics and genomics · 2015Article
- Attention-deficit/hyperactivity disorder genomics: update for clinicians.Current psychiatry reports · 2012Review
- Csnk1e is a genetic regulator of sensitivity to psychostimulants and opioids.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Article
- Substance use after participation in laboratory studies involving smoked cocaine self-administration.Drug and alcohol dependence · 2012Article
- Genetic factors modulating the response to stimulant drugs in humans.Current topics in behavioral neurosciences · 2012Review
- Dopamine transporter gene variant affecting expression in human brain is associated with bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Article
- The effects of progesterone pretreatment on the response to oral d-amphetamine in Women.Hormones and behavior · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Individuals vary in their subjective responses to stimulant drugs, and these differences are believed to be partially genetic in origin. We evaluated associations between mood, cognitive and cardiovascular responses to d-amphetamine and four polymorphisms in the dopamine transporter (SLC6A3): rs460000, rs3756450, rs37022 and rs6869645. Healthy Caucasian male and female volunteers (N = 152) participated in a double-blind, crossover design study in which they received placebo, 10 and 20 mg of d-amphetamine. We measured self-reported rating of mood, performance on the Digit Symbol Substitution Task, blood pressure and heart rate. Individuals with the C/C genotype at rs460000 (N = 83) reported approximately twofold higher ratings of stimulation and euphoria relative to the A/A+A/C (N = 69) genotype group, at both the 10 and 20 mg doses. No other responses or SNPs showed significant effects. rs460000 is in perfect LD with rs463379 (CEU: D' = 1; r (2) = 1), which was not studied here, but has been associated with etiology of Attention Deficit Hyperactivity Disorder (ADHD). These findings suggest a pleiotropic effect of this polymorphic locus on both ADHD and sensitivity to the subjective effects of amphetamine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.