ArticlePediatric nephrology (Berlin, Germany)2010
Tacrolimus nephrotoxicity: beware of the association of diarrhea, drug interaction and pharmacogenetics.
Article in Pediatric nephrology (Berlin, Germany), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 41 citations in OpenAlex.
- Structured Evaluation of Model-Informed Precision Dosing of Mycophenolic Acid and Tacrolimus in Pediatric Patients with Kidney Disease.Clinical pharmacokinetics · 2026Article
- Oxidative Stress-Driven Mechanisms and Biomarkers of Drug-Induced Nephrotoxicity: Translational Insights and Therapeutic Implications.Antioxidants (Basel, Switzerland) · 2026Review
- Post-transplant diarrhea in pediatric kidney transplant recipients.Pediatric nephrology (Berlin, Germany) · 2025Review
- Retinal transplant immunology and advancements.Stem cell reports · 2024Review
- Nerve Wrap for Local Delivery of FK506/Tacrolimus Accelerates Nerve Regeneration.International journal of molecular sciences · 2024Article
- Tacrolimus-Induced Diffuse Coronary Artery Spasm.Cureus · 2022Article
- Optimizing the Use of Antibiotic Agents in the Pediatric Intensive Care Unit: A Narrative Review.Paediatric drugs · 2021Review
- Case Report: Low Hematocrit Leading to Tacrolimus Toxicity.Frontiers in pharmacology · 2021Article
- Impacts of High Intra- and Inter-Individual Variability in Tacrolimus Pharmacokinetics and Fast Tacrolimus Metabolism on Outcomes of Solid Organ Transplant Recipients.Journal of clinical medicine · 2020Article
- Effects of Wuzhi Capsules on Blood Concentration of Tacrolimus in Renal Transplant Recipients.Annals of transplantation · 2019Article
- High tacrolimus blood concentrations early after lung transplantation and the risk of kidney injury.European journal of clinical pharmacology · 2017Article
- The influence of comedication on tacrolimus blood concentration in patients subjected to kidney transplantation: a retrospective study.European journal of drug metabolism and pharmacokinetics · 2014Article
- Raised tacrolimus level and acute renal injury associated with acute gastroenteritis in a child receiving local rectal tacrolimus.Clinical journal of gastroenterology · 2014Article
- Racial comparisons of everolimus pharmacokinetics and pharmacodynamics in adult kidney transplant recipients.Therapeutic drug monitoring · 2013Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tacrolimus is known to potentially lead to adverse events in recipients with diarrhoea and/or calcium channel blocker (CCB) co-administration. We report a renal transplant recipient who suffered from severe nephrotoxicity related to a toxic tacrolimus trough concentration in both conditions, diarrhoea and CCB co-administration, and with genotyped CYP3A system and P-glycoprotein (P-gp) polymorphisms. To our knowledge, this is the first case to be investigated for such polymorphisms. Clinicians should be reminded of the possibility of highly increased levels of tacrolimus in situations of diarrhoea and/or co-administration of CCBs. It also highlights the key role in tacrolimus pharmacokinetics of the CYP3A system and P-gp polymorphisms, and their influence in high-risk situations when enzyme activity is already affected by enterocyte damage due to diarrhoea and CCB competition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.