ArticlePLoS genetics2010
Irradiation-induced Deinococcus radiodurans genome fragmentation triggers transposition of a single resident insertion sequence.
Article in PLoS genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- One Plasmid Is All You Need: Genome Editing in Escherichia coli Using Endogenous TnpB and Endogenous Recombination System.Biotechnology and bioengineering · 2026Article
- Extremophile survives the transient pressures associated with impact-induced ejection from Mars.PNAS nexus · 2026Article
- An A-T Hoogsteen Base Pair in a Naked DNA Hairpin Motif: A Protein-Recognized Conformation.Angewandte Chemie (International ed. in English) · 2025Article
- A more significant role for insertion sequences in large-scale rearrangements in bacterial genomes.mBio · 2025Article
- Application of the transposon-associated TnpB system of CRISPR-Cas in bacteria:Frontiers in microbiology · 2025Review
- The Transposition of Insertion Sequences in Sigma-Factor- and LysR-Deficient Mutants ofMicroorganisms · 2024Article
- Comparative genomics ofFrontiers in microbiology · 2024Article
- Transposons and CRISPR: Rewiring Gene Editing.Biochemistry · 2023Article
- Article
- Targeted IS-element sequencing uncovers transposition dynamics during selective pressure in enterococci.PLoS pathogens · 2023Article
- Phylogenetic Relationships among TnpB-Containing Mobile Elements in Six Bacterial Species.Genes · 2023Article
- SLICER: A Seamless Gene Deletion Method forBiodesign research · 2023Article
- Hydrogen peroxide treatment induces the transposition of an insertion sequence inFrontiers in microbiology · 2023Article
- Ecophysiological and genomic analyses of a representative isolate of highly abundant Bacillus cereus strains in contaminated subsurface sediments.Environmental microbiology · 2022Article
- Active Transposition of Insertion Sequences in Prokaryotes: Insights from the Response ofAntioxidants (Basel, Switzerland) · 2022Review
- Frequency, composition and mobility of Escherichia coli-derived transposable elements in holdings of plasmid repositories.Microbial biotechnology · 2022Article
- Article
- Influence of Redox Imbalances on the Transposition of Insertion Sequences inAntioxidants (Basel, Switzerland) · 2021Article
- Coexistence of SOS-Dependent and SOS-Independent Regulation of DNA Repair Genes in Radiation-ResistantCells · 2021Review
- Article
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Stress-induced transposition is an attractive notion since it is potentially important in creating diversity to facilitate adaptation of the host to severe environmental conditions. One common major stress is radiation-induced DNA damage. Deinococcus radiodurans has an exceptional ability to withstand the lethal effects of DNA-damaging agents (ionizing radiation, UV light, and desiccation). High radiation levels result in genome fragmentation and reassembly in a process which generates significant amounts of single-stranded DNA. This capacity of D. radiodurans to withstand irradiation raises important questions concerning its response to radiation-induced mutagenic lesions. A recent study analyzed the mutational profile in the thyA gene following irradiation. The majority of thyA mutants resulted from transposition of one particular Insertion Sequence (IS), ISDra2, of the many different ISs in the D. radiodurans genome. ISDra2 is a member of a newly recognised class of ISs, the IS200/IS605 family of insertion sequences.
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