ArticlePLoS genetics2010
Non-coding changes cause sex-specific wing size differences between closely related species of Nasonia.
Article in PLoS genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed.
- Genome assembly and annotation of the parasitoid jewel wasp Nasonia oneida.Scientific data · 2025Article
- Marker-assisted mapping enables forward genetic analysis in Aedes aegypti, an arboviral vector with vast recombination deserts.Genetics · 2022Article
- Secondary reversion to sexual monomorphism associated with tissue-specific loss of doublesex expression.Evolution; international journal of organic evolution · 2022Article
- Genetic, morphometric, and molecular analyses of interspecies differences in head shape and hybrid developmental defects in the wasp genus Nasonia.G3 (Bethesda, Md.) · 2021Article
- The emergence of ecotypes in a parasitoid wasp: a case of incipient sympatric speciation in Hymenoptera?BMC ecology and evolution · 2021Article
- Quantitative genetics of wing morphology in the parasitoid wasp Nasonia vitripennis: hosts increase sibling similarity.Heredity · 2020Article
- Genetic architecture and sex-specific selection govern modular, male-biased evolution ofScience advances · 2019Article
- The Maternal Effect Gene Wds Controls Wolbachia Titer in Nasonia.Current biology : CB · 2018Article
- Evolving doublesex expression correlates with the origin and diversification of male sexual ornaments in the Drosophila immigrans species group.Evolution & development · 2018Article
- The pdm3 Locus Is a Hotspot for Recurrent Evolution of Female-Limited Color Dimorphism in Drosophila.Current biology : CB · 2016Article
- Dissection of the complex genetic basis of craniofacial anomalies using haploid genetics and interspecies hybrids in Nasonia wasps.Developmental biology · 2016Article
- Comparative Genomics of Two Closely Related Wolbachia with Different Reproductive Effects on Hosts.Genome biology and evolution · 2016Article
- Quantitative Trait Locus Analysis of Mating Behavior and Male Sex Pheromones in Nasonia Wasps.G3 (Bethesda, Md.) · 2016Article
- Evolution of Social Insect Polyphenism Facilitated by the Sex Differentiation Cascade.PLoS genetics · 2016Article
- Disentangling a Holobiont - Recent Advances and Perspectives inFrontiers in microbiology · 2016Review
- Double nexus--Doublesex is the connecting element in sex determination.Briefings in functional genomics · 2015Review
- Development of a Nasonia vitripennis outbred laboratory population for genetic analysis.Molecular ecology resources · 2014Article
- doublesex is a mimicry supergene.Nature · 2014Article
- Evolutionary biology: Sex, lies and butterflies.Nature · 2014Article
- Transcriptome profiling of Nasonia vitripennis testis reveals novel transcripts expressed from the selfish B chromosome, paternal sex ratio.G3 (Bethesda, Md.) · 2013Article
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Abstract
The genetic basis of morphological differences among species is still poorly understood. We investigated the genetic basis of sex-specific differences in wing size between two closely related species of Nasonia by positional cloning a major male-specific locus, wing-size1 (ws1). Male wing size increases by 45% through cell size and cell number changes when the ws1 allele from N. giraulti is backcrossed into a N. vitripennis genetic background. A positional cloning approach was used to fine-scale map the ws1 locus to a 13.5 kilobase region. This region falls between prospero (a transcription factor involved in neurogenesis) and the master sex-determining gene doublesex. It contains the 5'-UTR and cis-regulatory domain of doublesex, and no coding sequence. Wing size reduction correlates with an increase in doublesex expression level that is specific to developing male wings. Our results indicate that non-coding changes are responsible for recent divergence in sex-specific morphology between two closely related species. We have not yet resolved whether wing size evolution at the ws1 locus is caused by regulatory alterations of dsx or prospero, or by another mechanism. This study demonstrates the feasibility of efficient positional cloning of quantitative trait loci (QTL) involved in a broad array of phenotypic differences among Nasonia species.
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