ArticlePLoS pathogens2010
Type I interferon induction is detrimental during infection with the Whipple's disease bacterium, Tropheryma whipplei.
Article in PLoS pathogens, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Human genetics of Whipple's disease.Current opinion in rheumatology · 2025Review
- Article
- ExploringFrontiers in pharmacology · 2025Article
- Current knowledge of the immune reconstitution inflammatory syndrome in Whipple disease: a review.Frontiers in immunology · 2023Review
- Design of a Multi-Epitope Vaccine againstVaccines · 2022Article
- Review
- Tumor Necrosis Factor Inhibitors Exacerbate Whipple's Disease by Reprogramming Macrophage and Inducing Apoptosis.Frontiers in immunology · 2021Article
- Article
- TLR3 Activation of Intratumoral CD103Frontiers in immunology · 2019Article
- Type I interferon signaling attenuates regulatory T cell function in viral infection and in the tumor microenvironment.PLoS pathogens · 2018Article
- Clinical Manifestations, Treatment, and Diagnosis of Tropheryma whipplei Infections.Clinical microbiology reviews · 2017Review
- Type I interferons in infectious disease.Nature reviews. Immunology · 2015Review
- Article
- Phenotypic diversity and emerging new tools to study macrophage activation in bacterial infectious diseases.Frontiers in immunology · 2014Review
- Activation and regulation of interferon-β in immune responses.Immunologic research · 2012Review
- Identifying a role for Toll-like receptor 3 in the innate immune response to Chlamydia muridarum infection in murine oviduct epithelial cells.Infection and immunity · 2012Article
- Changing paradigms in Whipple's disease and infection with Tropheryma whipplei.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2011Review
- An experimental mouse model to establish Tropheryma whipplei as a diarrheal agent.The Journal of infectious diseases · 2011Article
- Orientia tsutsugamushi stimulates an original gene expression program in monocytes: relationship with gene expression in patients with scrub typhus.PLoS neglected tropical diseases · 2011Article
- Type I interferon production induced by Streptococcus pyogenes-derived nucleic acids is required for host protection.PLoS pathogens · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Macrophages are the first line of defense against pathogens. Upon infection macrophages usually produce high levels of proinflammatory mediators. However, macrophages can undergo an alternate polarization leading to a permissive state. In assessing global macrophage responses to the bacterial agent of Whipple's disease, Tropheryma whipplei, we found that T. whipplei induced M2 macrophage polarization which was compatible with bacterial replication. Surprisingly, this M2 polarization of infected macrophages was associated with apoptosis induction and a functional type I interferon (IFN) response, through IRF3 activation and STAT1 phosphorylation. Using macrophages from mice deficient for the type I IFN receptor, we found that this type I IFN response was required for T. whipplei-induced macrophage apoptosis in a JNK-dependent manner and was associated with the intracellular replication of T. whipplei independently of JNK. This study underscores the role of macrophage polarization in host responses and highlights the detrimental role of type I IFN during T. whipplei infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.