GuidelineAmerican journal of physical medicine & rehabilitation2010
Challenges and recommendations for placebo controls in randomized trials in physical and rehabilitation medicine: a report of the international placebo symposium working group.
Guideline in American journal of physical medicine & rehabilitation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 6 syntheses or guidelines pooled it, 116 citations in OpenAlex.
- Plausible Mechanism of Sham Acupuncture Based on Biomarkers: A Systematic Review of Randomized Controlled Trials.Frontiers in neuroscience · 2022Pooled it
- Transcranial electrical and magnetic stimulation (tES and TMS) for addiction medicine: A consensus paper on the present state of the science and the road ahead.Neuroscience and biobehavioral reviews · 2019Pooled it
- Rehabilitation interventions in randomized controlled trials for low back pain: proof of statistical significance often is not relevant.Health and quality of life outcomes · 2019Pooled it
- Pooled it
- Randomized sham-controlled trials in endoscopy: a systematic review and meta-analysis of adverse events.Gastrointestinal endoscopy · 2017Pooled it
- Acupuncture for Arthralgia Induced by Aromatase Inhibitors in Patients with Breast Cancer: A Systematic Review and Meta-analysis.Integrative cancer therapiesPooled it
- Effects of serial thermal brine hand baths on hand osteoarthritis: a randomized, double-blind, sham-controlled trial.European journal of physical and rehabilitation medicine · 2026Trial
- Virtual reality exergame in older patients with hypertension: a preliminary study to determine load intensity and blood pressure.BMC geriatrics · 2023Trial
- Effects of home-based leg heat therapy on walking performance in patients with symptomatic peripheral artery disease: a pilot randomized trial.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Trial
- Leg heat therapy improves perceived physical function but does not enhance walking capacity or vascular function in patients with peripheral artery disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Trial
- [Electrical muscle stimulation in combination with heat for patients with chronic, nonspecific low back pain : A randomized, double-blind, stratified, placebo-controlled clinical trial].Schmerz (Berlin, Germany) · 2020Trial
- Treatment of Symptomatic Convergence Insufficiency in Children Enrolled in the Convergence Insufficiency Treatment Trial-Attention & Reading Trial: A Randomized Clinical Trial.Optometry and vision science : official publication of the American Academy of Optometry · 2019Trial
- Non-invasive neuromodulation to improve gait in chronic multiple sclerosis: a randomized double blind controlled pilot trial.Journal of neuroengineering and rehabilitation · 2014Trial
- A randomized controlled trial of 8-form Tai chi improves symptoms and functional mobility in fibromyalgia patients.Clinical rheumatology · 2012Trial
- Trial
- Between a rock and a hard place: balancing roles of clinician and co-researcher in a primary health care setting - A qualitative study.Chiropractic & manual therapies · 2026Article
- Relevance of improved reporting for non-pharmacological interventions in clinical trials: Bridging research to clinical practice.Brazilian journal of physical therapy · 2026Review
- Can new approaches to synthesising evidence help achieve a consensus in psychotherapy research?Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists · 2024Article
- Techniques for randomization and allocation for clinical trials.Jornal vascular brasileiro · 2024Review
- Why Does Rehabilitation Not (Always) Work in Osteoarthritis? Does Rehabilitation Need Molecular Biology?International journal of molecular sciences · 2023Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Compared with other specialties, the field of physical and rehabilitation medicine has not received the deserved recognition from clinicians and researchers in the scientific community. One of the reasons is the lack of sound evidence to support the traditional physical and rehabilitation medicine treatments. The best way to change this disadvantage is through a well conducted clinical research, such as standard placebo- or sham-controlled randomized clinical trials. Therefore, having placebo groups in clinical trials is essential to improve the level of evidence-based practice in physical and rehabilitation medicine that ultimately translates to better clinical care. To address the challenges for the use of placebo in physical and rehabilitation medicine and randomized clinical trials and to create useful recommendations, we convened a working group during the inaugural International Symposium in Placebo (February 2009, in Sao Paulo, Brazil) in which the following topics were discussed: (1) current status of randomized clinical trials in physical and rehabilitation medicine, (2) challenges for the use of placebo in physical and rehabilitation medicine, (3) bioethics, (4) use of placebo in acupuncture trials and for the treatment of low-back pain, (5) mechanisms of placebo, and (6) insights from other specialties. The current article represents the consensus report from the working group.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.