ReviewJournal of genetics2009
Molecular complexity of primary open angle glaucoma: current concepts.
Review in Journal of genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 70 citations in OpenAlex.
- Synthesis and Enzymatic Evaluation of a Small Library of Substituted Phenylsulfonamido-Alkyl Sulfamates towards Carbonic Anhydrase II.Molecules (Basel, Switzerland) · 2024Article
- Exploring the role of apolipoprotein E gene promoter polymorphisms in susceptibility to normal-tension glaucoma in a Korean population.Scientific reports · 2024Article
- Bidirectional association between glaucoma and chronic kidney disease: A systematic review and meta-analysis.EClinicalMedicine · 2022Article
- Trabecular Meshwork Mitochondrial Function and Oxidative Stress: Clues to Racial Disparities of Glaucoma.Ophthalmology science · 2022Article
- Significance of the lncRNAs MALAT1 and ANRIL in occurrence and development of glaucoma.Journal of clinical laboratory analysis · 2022Article
- Evaluating the Correlation between Alzheimer's Amyloid-β Peptides and Glaucoma in Human Aqueous Humor.Translational vision science & technology · 2020Article
- Reactive Oxygen Species-Mediated Damage of Retinal Neurons: Drug Development Targets for Therapies of Chronic Neurodegeneration of the Retina.International journal of molecular sciences · 2018Review
- Early changes of brain connectivity in primary open angle glaucoma.Human brain mapping · 2016Article
- Induced pluripotent stem cells restore function in a human cell loss model of open-angle glaucoma.Stem cells (Dayton, Ohio) · 2015Article
- The genetics of POAG in black South Africans: a candidate gene association study.Scientific reports · 2015Article
- Alterations in molecular pathways in the retina of early experimental glaucoma eyes.International journal of physiology, pathophysiology and pharmacology · 2015Article
- BDNF and HSP gene polymorphisms and their influence on the progression of primary open-angle glaucoma in a Polish population.Archives of medical science : AMS · 2014Article
- Gene-rich large deletions are overrepresented in POAG patients of Indian and Caucasian origins.Investigative ophthalmology & visual science · 2014Article
- Activation of muscarinic receptors protects against retinal neurons damage and optic nerve degeneration in vitro and in vivo models.CNS neuroscience & therapeutics · 2014Article
- Prevalence of glaucoma in an urban West African population: the Tema Eye Survey.JAMA ophthalmology · 2013Article
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- Analysis of COCH and TNFA variants in East Indian primary open-angle glaucoma patients.BioMed research international · 2013Article
- Tbl3 regulates cell cycle length during zebrafish development.Developmental biology · 2012Article
- An approach to predict the risk of glaucoma development by integrating different attribute data.SpringerPlus · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glaucoma is a group of heterogeneous optic neuropathies with complex genetic basis. Among the three principle subtypes of glaucoma, primary open angle glaucoma (POAG) occurs most frequently. Till date, 25 loci have been found to be linked to POAG. However, only three underlying genes (Myocilin, Optineurin and WDR36) have been identified. In addition, at least 30 other genes have been reported to be associated with POAG. Despite strong genetic influence in POAG pathogenesis, only a small part of the disease can be explained in terms of genetic aberration. Current concepts of glaucoma pathogenesis suggest it to be a neurodegenerative disorder which is triggered by different factors including mechanical stress due to intra-ocular pressure, reduced blood flow to retina, reperfusion injury, oxidative stress, glutamate excitotoxicity, and aberrant immune response. Here we present a mechanistic overview of potential pathways and crosstalk between them operating in POAG pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.