ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Rapid, learning-induced inhibitory synaptogenesis in murine barrel field.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 71 citations in OpenAlex.
- Synaptic Plasticity Changes in the Somatosensory Cortex During Amyotrophic Lateral Sclerosis Progression and After Swim Training in SOD1-G93A Mice.Molecular neurobiology · 2026Article
- Spine-neck electrical bottlenecks tune temporal precision and inhibitory gating in cortical pyramidal neurons: A connectomics-based biophysical study.bioRxiv : the preprint server for biology · 2026Article
- Conditional learning increases inhibition of layer 4 excitatory neurons by somatostatin- and parvalbumin-expressing interneurons in the barrel cortex.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Learning, prediction accuracy, and neural plasticity in sensory cortex.Current opinion in neurobiology · 2025Review
- Light-Modulated Circadian Synaptic Plasticity in the Somatosensory Cortex: Link to Locomotor Activity.International journal of molecular sciences · 2024Article
- Mitigation of aging-related plasticity decline through taurine supplementation and environmental enrichment.Scientific reports · 2024Article
- Transient enhancement of stimulus-evoked activity in neocortex during sensory learning.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Conditioning and pseudoconditioning differently change intrinsic excitability of inhibitory interneurons in the neocortex.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Shh activation restores interneurons and cognitive function in newborns with intraventricular haemorrhage.Brain : a journal of neurology · 2023Article
- Synaptic modifications in learning and memory - A dendritic spine story.Seminars in cell & developmental biology · 2022Review
- Theoretical modeling of dendrite growth from conductive wire electro-polymerization.Scientific reports · 2022Article
- Traceable stimulus-dependent rapid molecular changes in dendritic spines in the brain.Scientific reports · 2020Article
- A Cellular Mechanism of Learning-Induced Enhancement of Synaptic Inhibition: PKC-Dependent Upregulation of KCC2 Activation.Scientific reports · 2020Article
- Circadian Changes of Dendritic Spine Geometry in Mouse Barrel Cortex.Frontiers in neuroscience · 2020Article
- Review
- Circadian clock regulates the shape and content of dendritic spines in mouse barrel cortex.PloS one · 2019Article
- GABA type a receptor trafficking and the architecture of synaptic inhibition.Developmental neurobiology · 2018Review
- Current Perspectives regarding Stem Cell-Based Therapy for Alzheimer's Disease.Stem cells international · 2018Review
- Spike Timing-Dependent Plasticity in the Mouse Barrel Cortex Is Strongly Modulated by Sensory Learning and Depends on Activity of Matrix Metalloproteinase 9.Molecular neurobiology · 2017Article
- The space where aging acts: focus on the GABAergic synapse.Aging cell · 2017Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
The structure of neurons changes during development and in response to injury or alteration in sensory experience. Changes occur in the number, shape, and dimensions of dendritic spines together with their synapses. However, precise data on these changes in response to learning are sparse. Here, we show using quantitative transmission electron microscopy that a simple form of learning involving mystacial vibrissae results in approximately 70% increase in the density of inhibitory synapses on spines of neurons located in layer IV barrels that represent the stimulated vibrissae. The spines contain one asymmetrical (excitatory) and one symmetrical (inhibitory) synapse (double-synapse spines), and their density increases threefold as a result of learning with no apparent change in the density of asymmetrical synapses. This effect seems to be specific for learning because pseudoconditioning (in which the conditioned and unconditioned stimuli are delivered at random) does not lead to the enhancement of symmetrical synapses but instead results in an upregulation of asymmetrical synapses on spines. Symmetrical synapses of cells located in barrels receiving the conditioned stimulus also show a greater concentration of GABA in their presynaptic terminals. These results indicate that the immediate effect of classical conditioning in the "conditioned" barrels is rapid, pronounced, and inhibitory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.