ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Assembly and stoichiometry of the AMPA receptor and transmembrane AMPA receptor regulatory protein complex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 80 citations in OpenAlex.
- GARLH regulates neuroligin preference for excitatory versus inhibitory synapses.The Journal of cell biology · 2026Article
- Chemogenetic regulation of the TARP-lipid interaction mimics LTP and reversibly modifies behavior.Cell reports · 2023Article
- Influence of the TARP γ8-Selective Negative Allosteric Modulator JNJ-55511118 on AMPA Receptor Gating and Channel Conductance.Molecular pharmacology · 2022Article
- Identification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function.PLoS biology · 2022Article
- Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.Pharmacological reviews · 2021Review
- Review
- Auxiliary Subunits Regulate the Dendritic Turnover of AMPA Receptors in Mouse Hippocampal Neurons.Frontiers in molecular neuroscience · 2021Article
- Structural and functional insights into transmembrane AMPA receptor regulatory protein complexes.The Journal of general physiology · 2019Review
- Molecular constituents and localization of the ionotropic GABA receptor complex in vivo.Current opinion in neurobiology · 2019Review
- AMPA receptors and their minions: auxiliary proteins in AMPA receptor trafficking.Cellular and molecular life sciences : CMLS · 2019Review
- Functional organization of postsynaptic glutamate receptors.Molecular and cellular neurosciences · 2018Review
- Article
- Assembly rules for GABAeLife · 2017Article
- Dual Effects of TARP γ-2 on Glutamate Efficacy Can Account for AMPA Receptor Autoinactivation.Cell reports · 2017Article
- GARLH Family Proteins Stabilize GABANeuron · 2017Article
- GluA1 signal peptide determines the spatial assembly of heteromeric AMPA receptors.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Elucidation of AMPA receptor-stargazin complexes by cryo-electron microscopy.Science (New York, N.Y.) · 2016Article
- Aggregation Limits Surface Expression of Homomeric GluA3 Receptors.The Journal of biological chemistry · 2016Article
- TARP γ-2 and γ-8 Differentially Control AMPAR Density Across Schaffer Collateral/Commissural Synapses in the Hippocampal CA1 Area.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- The Transmembrane Domain Mediates Tetramerization of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors.The Journal of biological chemistry · 2016Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Glutamate is a major excitatory neurotransmitter in the vertebrate brain. AMPA-type glutamate receptors mediate fast excitatory transmission. AMPA receptors assemble with transmembrane AMPA receptor regulatory protein (TARP) auxiliary subunits and function as native ion channels. However, the assembly and stoichiometry of AMPA receptor and TARP complexes remain unclear. Here, we developed a novel strategy to determine the assembly and stoichiometry of this protein complex and found that functional AMPA receptors indeed assembled as a tetramer in a dimer-of-dimers structure. Furthermore, we found that the AMPA receptor auxiliary subunit, TARP, had a variable stoichiometry (1-4 TARP units) on AMPA receptors and that 1 TARP unit was sufficient to modulate AMPA receptor activity. In neurons, TARP had fixed and minimum stoichiometry on AMPA receptors. This fundamental composition of the AMPA receptor/TARP complex is important for the elucidation of the molecular machinery that underlies synaptic transmission.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.