ArticleInvestigative ophthalmology & visual science2010
Effects of sildenafil and tadalafil on intraocular pressure in sheep: implications for aqueous humor dynamics.
Article in Investigative ophthalmology & visual science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 36 citations in OpenAlex.
- Ocular safety of sildenafil citrate when administered chronically for pulmonary arterial hypertension: results from phase III, randomised, double masked, placebo controlled trial and open label extension.BMJ (Clinical research ed.) · 2012Trial
- Effect of sildenafil citrate on intraocular pressure and blood pressure in human volunteers.Experimental eye research · 2011Trial
- [Chorioretinal folds of interesting etiology].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2020Article
- Precautions and Monitoring of Patients Taking Phosphodiesterase Type 5 Inhibitors Who are at Risk of Increased Intraocular Pressure.Drugs & aging · 2019Review
- Increased bioavailability of cyclic guanylate monophosphate prevents retinal ganglion cell degeneration.Neurobiology of disease · 2019Article
- Inhibition of calpain delays early muscle atrophy after rotator cuff tendon release in sheep.Physiological reports · 2018Article
- Effect of periodic sildenafil dosage on intraocular pressure in patients with erectile dysfunction.Electronic physician · 2017Article
- Ocular perfusion pressure and color Doppler imaging of the external ophthalmic artery of rabbits treated with sildenafil citrate.BMC veterinary research · 2016Article
- Pathophysiology of visual disorders induced by phosphodiesterase inhibitors in the treatment of erectile dysfunction.Drug design, development and therapy · 2016Review
- Sildenafil stimulates aqueous humor turnover in rabbits.Experimental eye research · 2013Article
- Sildenafil dilates ophthalmic artery in type 2 diabetic patients.SAGE open medicine · 2013Article
- Sildenafil accelerates anterior chamber refilling after paracentesis in sheep and rabbits.Investigative ophthalmology & visual science · 2012Article
- Article
- Phosphodiesterase Type 5 Inhibitors and Visual Side Effects: A Narrative Review.Journal of ophthalmic & vision researchReview
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeTo determine the effects of vasodilators on intraocular pressure (IOP) and the protein content of sheep aqueous humor (AH), because the vasodilators may increase fluid leakage from the fenestrated capillaries of the ciliary body to the extracellular tissue and directly to the anterior chamber (AC) via the iris, and some senior patients (older than 70) treated with sildenafil have exhibited elevated IOP.
methodsExperiments were performed on domestic sheep residing on a ranch in Argentina. These docile and compliant animals readily swallowed tablets of sildenafil (50 and 100 mg) and tadalafil (20 mg). IOP was monitored by Perkins applanation tonometry in 21 normal sheep receiving orally administered drugs. In addition, paracentesis was performed on six sheep to quantify changes in AH protein levels.
resultsIngestion of both sildenafil and tadalafil increased sheep IOP from normal levels of approximately 9 to 11 mm Hg within 1 hour. The IOP elevation was approximately 1.6-fold with both doses of sildenafil. IOP returned to control values within 4 hours. With the longer-lasting vasodilator tadalafil, IOP remained 1.6- to 1.9-fold higher than normal for at least 48 hours and returned to control levels within 4 days. The AH protein content was approximately 39% higher in sheep given 100 mg sildenafil.
conclusionsThese data are consistent with a vasodilator-evoked increase in plasma-like fluid in the AC, which likely accounts for the IOP elevation. The results are discussed with a model for AH dynamics that may be of importance to senior individuals treated for vascular diseases with these compounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.