ArticleInvestigative ophthalmology & visual science2010
Effect of EGF-induced HDAC6 activation on corneal epithelial wound healing.
Article in Investigative ophthalmology & visual science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 17 citations in OpenAlex.
- Lactate-fueled H3K18 lactylation sustains ΔNp63α-dependent self-renewal in limbal epithelial stem cells.The Journal of biological chemistry · 2026Article
- Histone Acetylation Landscape and the Role of HAT1 in Regulating Corneal Epithelial Wound Healing.Investigative ophthalmology & visual science · 2026Article
- Role of Histone Deacetylase 6 and Histone Deacetylase 6 Inhibition in Colorectal Cancer.Pharmaceutics · 2023Review
- Sirt1 Regulates Corneal Epithelial Migration by Deacetylating Cortactin.Investigative ophthalmology & visual science · 2022Article
- A Novel Therapeutic Approach to Corneal Alkaline Burn Model by Targeting Fidgetin-Like 2, a Microtubule Regulator.Translational vision science & technology · 2021Article
- Tumour Expression of Histone Deacetylases in Uveal Melanoma.Ocular oncology and pathology · 2019Article
- Cigarette Smoke Disrupted Lung Endothelial Barrier Integrity and Increased Susceptibility to Acute Lung Injury via Histone Deacetylase 6.American journal of respiratory cell and molecular biology · 2016Article
- CTCF-Mediated and Pax6-Associated Gene Expression in Corneal Epithelial Cell-Specific Differentiation.PloS one · 2016Article
- Progress in corneal wound healing.Progress in retinal and eye research · 2015Review
- The role of endogenous epidermal growth factor receptor ligands in mediating corneal epithelial homeostasis.Investigative ophthalmology & visual science · 2014Article
- Inhibition of ataxia telangiectasia mutated (ATM) kinase suppresses herpes simplex virus type 1 (HSV-1) keratitis.Investigative ophthalmology & visual science · 2014Article
- Epidermal growth factor (EGF)-induced corneal epithelial wound healing through nuclear factor κB subtype-regulated CCCTC binding factor (CTCF) activation.The Journal of biological chemistry · 2013Article
- HDAC6 deacetylase activity is required for hypoxia-induced invadopodia formation and cell invasion.PloS one · 2013Article
- Role of CTCF in EGF-induced migration of immortalized human corneal epithelial cells.Investigative ophthalmology & visual science · 2012Article
- The role of eIF5A in epidermal growth factor-induced proliferation of corneal epithelial cell association with PI3-k/Akt activation.Molecular vision · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposeEpidermal growth factor (EGF) stimulates migration in corneal epithelial wound healing. The purpose of this study was to investigate the effect of EGF-induced alpha-tubulin deacetylation through activating HDAC6 on migration in corneal epithelial wound healing.
methodsHuman corneal epithelial (HCE) cells were cultured in DMEM/F12 medium containing 10% FBS in a 37 degrees C incubator supplied with 5% CO(2). Western blot analysis was used to determine protein expression. Activity of HDAC6 was suppressed by trichostatin A (TSA) and by siRNA specific to HDAC6. Corneal epithelial cell migration was measured by using scratch-induced directional migration assay in cultured cells and by corneal epithelial debridement using a mouse whole-eye organ culture model.
resultsThe authors found EGF stimulated corneal epithelial cell migration in wound healing by enhancing HDAC6 activity, resulting in the deacetylation of alpha-tubulin. EGF stimulated HDAC6 enzymatic activity and protein translocation toward the leading edge of the cell. Inhibition of HDAC6 activity by TSA significantly suppressed EGF-induced cell migration and delayed EGF-induced wound healing in epithelially debrided mouse corneas. In the meantime, knockdown of HDAC6 mRNA with specific siRNA effectively abolished EGF-induced deacetylation of alpha-tubulin, resulting in the inhibition of cell migration.
conclusionsThese results reveal an important mechanism that involves EGF-induced HDAC6 activation and alpha-tubulin deacetylation, subsequently affecting corneal epithelial migration in the wound-healing process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.