ArticlePlant physiology2010
R2R3-NaMYB8 regulates the accumulation of phenylpropanoid-polyamine conjugates, which are essential for local and systemic defense against insect herbivores in Nicotiana attenuata.
Article in Plant physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.
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112 citing papers in PubMed, 242 citations in OpenAlex.
- Molecular and transcriptional regulation of plant defense responses to aphid infestation.Stress biology · 2026Review
- The zig-zag model of molecular defense and counterdefense in plant-herbivore interactions.Planta · 2026Review
- Phenolamide-driven α-glucosidase inhibitory activity in immature fruits of the Korean landrace-derived chili pepper Sumihyang.Plant molecular biology · 2026Article
- Untargeted metabolomics suggests a trade-off between phenolamides and flavonoids in the pollen of Petunia hybrida with contrasting flower colours.BMC plant biology · 2026Article
- MYC2b-regulated tyramine-derived phenolamides in maize defense againstFrontiers in plant science · 2026Article
- Analysis of biosynthetic genes of phenolamides inFrontiers in plant science · 2026Article
- Change Your Diet: How COMolecular ecology · 2025Article
- Expanded functional roles of R2R3-MYB (S6) transcription factors in balancing phenylpropanoid and phenolamide pathways in Solanaceae.Plant & cell physiology · 2025Article
- The G-protein β subunit SlGB1 regulates tyramine-derived phenolamide metabolism for shoot apex growth and development in tomato.The Plant cell · 2025Article
- Hydroxycinnamic acid amides in rice: biosynthesis, distribution, function, and implication for crop development.Frontiers in plant science · 2025Review
- OsMYB1 antagonizes OsSPL14 to mediate rice resistance to brown planthopper and Xanthomonas oryzae pv. oryzae.Plant cell reports · 2024Article
- In vitro strategy to enhance the production of bioactive polyphenols and caffeoylputrescine in the hairy roots of Physalis peruviana L.Scientific reports · 2024Article
- Temporal transcriptome and metabolome study revealed molecular mechanisms underlying rose responses to red spider mite infestation and predatory mite antagonism.Frontiers in plant science · 2024Article
- Enhanced chemical and physical defense traits in a rice cultivar showing resistance to leaffolder infestation.Crop health · 2023Article
- Identification and profile of phenolamides with anthracnose resistance potential in tea (Horticulture research · 2023Article
- A persistent major mutation in canonical jasmonate signaling is embedded in an herbivory-elicited gene network.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Small Brown Planthopper Nymph Infestation Regulates Plant Defenses by Affecting Secondary Metabolite Biosynthesis in Rice.International journal of molecular sciences · 2023Article
- Thermal tolerance role of novel polyamine, caldopentamine, identified in fifth instar Bombyx mori.Amino acids · 2023Article
- GhMYB18 confers Aphis gossypii Glover resistance through regulating the synthesis of salicylic acid and flavonoids in cotton plants.Plant cell reports · 2023Article
- Identifying Soybean Pod Borer (International journal of molecular sciences · 2022Article
52 more citing papers are in PubMed but not listed here.
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5 authors at 1 institution in 1 country.
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Abstract
Although phenylpropanoid-polyamine conjugates (PPCs) occur ubiquitously in plants, their biological roles remain largely unexplored. The two major PPCs of Nicotiana attenuata plants, caffeoylputrescine (CP) and dicaffeoylspermidine, increase dramatically in local and systemic tissues after herbivore attack and simulations thereof. We identified NaMYB8, a homolog of NtMYBJS1, which in BY-2 cells regulates PPC biosynthesis, and silenced its expression by RNA interference in N. attenuata (ir-MYB8), to understand the ecological role(s) of PPCs. The regulatory role of NaMYB8 in PPC biosynthesis was validated by a microarray analysis, which revealed that transcripts of several key biosynthetic genes in shikimate and polyamine metabolism accumulated in a NaMYB8-dependent manner. Wild-type N. attenuata plants typically contain high levels of PPCs in their reproductive tissues; however, NaMYB8-silenced plants that completely lacked CP and dicaffeoylspermidine showed no changes in reproductive parameters of the plants. In contrast, a defensive role for PPCs was clear; both specialist (Manduca sexta) and generalist (Spodoptera littoralis) caterpillars feeding on systemically preinduced young stem leaves performed significantly better on ir-MYB8 plants lacking PPCs compared with wild-type plants expressing high levels of PPCs. Moreover, the growth of M. sexta caterpillars was significantly reduced when neonates were fed ir-MYB8 leaves sprayed with synthetic CP, corroborating the role of PPCs as direct plant defense. The spatiotemporal accumulation and function of PPCs in N. attenuata are consistent with the predictions of the optimal defense theory: plants preferentially protect their most fitness-enhancing and vulnerable parts, young tissues and reproductive organs, to maximize their fitness.
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