ArticleJournal of clinical microbiology2010
Predominance and emergence of clones of hospital-acquired methicillin-resistant Staphylococcus aureus in Malaysia.
Article in Journal of clinical microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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Who cites it
70 citing papers in PubMed.
- Characterization of methicillin-resistant Staphylococcus aureus strains recovered from a phase IV clinical trial for linezolid versus vancomycin for treatment of nosocomial pneumonia.Journal of clinical microbiology · 2012Trial
- Molecular detection of phenol-soluble modulin-mec (PSM-mec) in Staphylococcus aureus clinical isolates from Federal Medical Center Birnin Kebbi, North-West, Nigeria.GMS hygiene and infection control · 2025Article
- Dissecting the genetic features and evolution ofmSystems · 2024Article
- Molecular Evolution and Pathogenicity of Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2024Article
- Pathogenomic profile and clonal diversity of potential zoonotic MRSA-CC7-ST789-t091-SCCmecV from human skin and soft tissue infections.Scientific reports · 2024Article
- Whole genome sequencing of methicillin-resistant Staphylococcus aureus clinical isolates from Terengganu, Malaysia, indicates the predominance of the EMRSA-15 (ST22-SCCmec IV) clone.Scientific reports · 2024Article
- Article
- Dissemination Pattern of Hospital-Acquired Methicillin-ResistantThe Malaysian journal of medical sciences : MJMS · 2023Review
- Multidrug-Resistant Methicillin-ResistantDiagnostics (Basel, Switzerland) · 2023Article
- Diversity and Dissemination of Methicillin-ResistantTropical medicine and infectious disease · 2022Review
- Genetic Diversity among Methicillin-ResistantTropical medicine and infectious disease · 2022Review
- High prevalence and expression of antiseptic resistance genes among infectious t037/ST239 methicillin-resistantIranian journal of basic medical sciences · 2022Article
- Contribution of Arginine Catabolic Mobile Element and Copper and Mercury Resistance Element in Methicillin-ResistantThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2022Review
- Staphylococcal Cassette ChromosomeInfection and drug resistance · 2022Article
- Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2021Article
- Genomic analysis revealed a novel genotype of methicillin-susceptible Staphylococcus aureus isolated from a fatal sepsis case in dengue patient.Scientific reports · 2021Article
- Colonization withMicrobial genomics · 2021Article
- The Role of Subinhibitory Concentrations of Daptomycin and Tigecycline in Modulating Virulence inAntibiotics (Basel, Switzerland) · 2021Article
- Investigation of Virulence Genes ofThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2021Article
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10 more citing papers are in PubMed but not listed here.
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11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We define the epidemiology of predominant and sporadic methicillin-resistant Staphylococcus aureus (MRSA) strains in a central teaching and referral hospital in Kuala Lumpur, Malaysia. This is done on the basis of spa sequencing, multilocus sequence typing (MLST), staphylococcal cassette chromosome mec (SCCmec) typing, and virulence gene profiling. During the period of study, the MRSA prevalence was 44.1%, and 389 MRSA strains were included. The prevalence of MRSA was found to be significantly higher in the patients of Indian ethnicity (P < 0.001). The majority (92.5%) of the isolates belonged to ST-239, spa type t037, and possessed the type III or IIIA SCCmec. The arginine catabolic mobile element (ACME) arcA gene was detected in three (1.05%) ST-239 isolates. We report the first identification of ACME arcA gene-positive ST-239. Apart from this predominant clone, six (1.5%) isolates of ST-22, with two related spa types (t032 and t4184) and a singleton (t3213), carrying type IVh SCCmec, were detected for the first time in Asia. A limited number of community-acquired (CA) MRSA strains were also detected. These included ST-188/t189 (2.1%), ST-1/t127 (2.3%), and ST-7/t091 (1%). Panton-Valentin leukocidin (PVL) was detected in all ST-1 and ST-188 strains and in 0.7% of the ST-239 isolates. The majority of the isolates carried agr I, except that ST-1 strains were agr III positive. Virulence genes seg and sei were seen only among ST-22 isolates. In conclusion, current results revealed the predominance of ST-239-SCCmec III/IIIA and the penetration of ST-22 with different virulence gene profiles. The emergence in Malaysia of novel clones of known epidemic and pathogenic potential should be taken seriously.
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