Evidence map›Paper›PMID 20089734›Full record

ReviewThe American journal of clinical nutrition2010

Saturated fat, carbohydrate, and cardiovascular disease.

Patty W Siri-Tarino, Qi Sun, Frank B Hu, Ronald M Krauss

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The American journal of clinical nutrition, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01929551 (Comparison of the Glycemic Index of a Drink Made of Natural Concentrated Mango Puree With Natural Concentrated Pear Juice With That of Other Five Products Based on Mango and Pear in Different Solid Products and Drinks), which is not on this map. Cited by 187 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
187citing papers in PubMed, 11 pooled it
31.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01929551 nacompletednot on this mapstarted 2013, after this paper: background citation

Comparison of the Glycemic Index of a Drink Made of Natural Concentrated Mango Puree With Natural Concentrated Pear Juice With That of Other Five Products Based on Mango and Pear in Different Solid Products and Drinks

TypeinterventionalSponsorInstituto Tecnologico y de Estudios Superiores de MontereyRan2013 to 2013Enrolled38ConditionsGlucose IntoleranceArmsMango puree and pear juice beverage, Commercial mango juice, Fresh natural mango, Frozen natural mango, Processed natural mango pulp
3 · Its place in the literature

Who cites it

187 citing papers in PubMed, 11 syntheses or guidelines pooled it, 631 citations in OpenAlex.

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  10. Green and black tea for the primary prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2013
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127 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Patty W Siri-TarinoDepartment of Atherosclerosis Research Children's Hospital Oakland Research Institute Oakland, CA, USA.
Qi Sun
Frank B Hu
Ronald M Krauss
Harvard University · US

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
DIETARY PATTERNS AND RISK OF CARDIOVASCULAR DISEASER01HL060712 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI HU, FRANK B, QI, QIBIN · 1998 to 2021
$8.0M
NCRR NIH HHS UL1 RR024131-01NHLBI NIH HHS HL60712
6 · The paper itself

Abstract

A focus of dietary recommendations for cardiovascular disease (CVD) prevention and treatment has been a reduction in saturated fat intake, primarily as a means of lowering LDL-cholesterol concentrations. However, the evidence that supports a reduction in saturated fat intake must be evaluated in the context of replacement by other macronutrients. Clinical trials that replaced saturated fat with polyunsaturated fat have generally shown a reduction in CVD events, although several studies showed no effects. An independent association of saturated fat intake with CVD risk has not been consistently shown in prospective epidemiologic studies, although some have provided evidence of an increased risk in young individuals and in women. Replacement of saturated fat by polyunsaturated or monounsaturated fat lowers both LDL and HDL cholesterol. However, replacement with a higher carbohydrate intake, particularly refined carbohydrate, can exacerbate the atherogenic dyslipidemia associated with insulin resistance and obesity that includes increased triglycerides, small LDL particles, and reduced HDL cholesterol. In summary, although substitution of dietary polyunsaturated fat for saturated fat has been shown to lower CVD risk, there are few epidemiologic or clinical trial data to support a benefit of replacing saturated fat with carbohydrate. Furthermore, particularly given the differential effects of dietary saturated fats and carbohydrates on concentrations of larger and smaller LDL particles, respectively, dietary efforts to improve the increasing burden of CVD risk associated with atherogenic dyslipidemia should primarily emphasize the limitation of refined carbohydrate intakes and a reduction in excess adiposity.

Indexed as

DietAtherosclerosisCardiovascular DiseasesCholesterol, HDLCholesterol, LDLDietary CarbohydratesDietary FatsDyslipidemiasFatty AcidsFatty Acids, UnsaturatedHealth PromotionHumansObesityRisk FactorsCholesterol, HDLCholesterol, LDLDietary CarbohydratesDietary FatsFatty AcidsFatty Acids, Unsaturated

Identifiers

PMID20089734
PMCPMC2824150
OpenAlexW2143915650

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.