Trial reportThe American journal of clinical nutrition2010
Dietary predictors of the insulin-like growth factor system in adolescent females: results from the Dietary Intervention Study in Children (DISC).
Trial report in The American journal of clinical nutrition, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00000459 (Dietary Intervention Study in Children), which is not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dietary Intervention Study in Children (DISC)
Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Effects of milk powder intervention on bone mineral density and indicators related to bone metabolism in Chinese adolescents.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Trial
- Growth parameters and IGF-1 axis biomarkers differ among omnivorous, vegetarian, and vegan children.European journal of nutrition · 2026Observational
- Dietary patterns associated with benign breast nodules by subtypes: a cross-sectional study in southeast China.Frontiers in nutrition · 2025Article
- Association of Traditional dietary pattern with early and precocious puberty: a population-based cross-sectional study.Pediatric research · 2024Article
- Dietary pattern and precocious puberty risk in Chinese girls: a case-control study.Nutrition journal · 2024Article
- Review Nutritional interventions during adolescence and their possible effects.Acta bio-medica : Atenei Parmensis · 2022Review
- Adherence to plant-based dietary pattern and risk of breast cancer among Iranian women.European journal of clinical nutrition · 2021Article
- Dietary intake from birth through adolescence in relation to risk of benign breast disease in young women.Breast cancer research and treatment · 2019Article
- Associations of lifestyle factors with serum dehydroepiandrosterone sulphate and insulin-like growth factor-1 concentration in prepubertal children.Clinical endocrinology · 2018Article
- Adolescent intake of animal fat and red meat in relation to premenopausal mammographic density.Breast cancer research and treatment · 2016Article
- The effects of dietary protein and amino acids on skeletal metabolism.Molecular and cellular endocrinology · 2015Review
- Adolescent dietary fiber, vegetable fat, vegetable protein, and nut intakes and breast cancer risk.Breast cancer research and treatment · 2014Article
- Article
- Milk intake and total dairy consumption: associations with early menarche in NHANES 1999-2004.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe insulin-like growth factor (IGF) system is associated with the adult diet and chronic disease. Childhood diet may influence chronic disease through its effect on the IGF system; however, there is limited information describing the dietary predictors of the IGF system in adolescents.
objectiveWe examined associations between dietary food intake [fat, protein (animal and vegetable), carbohydrate, lactose, dietary fiber, calcium, zinc, and sodium] and serum IGF-I, IGF binding protein 1 (IGFBP-1), IGF binding protein 3 (IGFBP-3), and the IGF-I:IGFBP-3 molar ratio in adolescent females.
designOne hundred fifty-nine adolescent females in the Dietary Intervention Study in Children (age range: 14-18 y; 0.2-6.3 y postmenarche) were included. The dietary intake was assessed via three 24-h dietary recalls. IGF-related biomarkers were determined by using radioimmunoassays. Associations between dietary intakes and biomarkers were assessed with Pearson's correlations and multivariable linear regression. Dietary intakes and biomarkers were logarithmically transformed; thus, beta coefficients represented percentages.
resultsIn analyses adjusted for energy, age, and time since menarche, significant correlations (P < 0.05) were as follows: IGF-I with total protein, lactose, calcium, and sodium; IGFBP-3 with total fat (inverse), lactose, fiber, and calcium; IGF-I/IGFBP-3 with lactose and calcium; and IGFBP-1 with vegetable protein. In multivariable analyses, significant predictors of IGF-I were energy (beta = 0.14, P < 0.05) and calcium (beta = 0.14, P < 0.01), the significant predictor of IGFBP-3 was calcium (beta = 0.07, P < 0.05), and significant predictors of IGFBP-1 were vegetable protein (beta = 0.49, P < 0.05) and body mass index-for-age percentile (beta = -0.01, P < 0.001).
conclusionThis study provides evidence that dietary intake affects IGF-related biomarkers-particularly elevated calcium with IGF-I and IGFBP-3 and elevated vegetable protein with IGFBP-1-and, to our knowledge, is novel in reporting these associations in adolescent females. The Dietary Intervention Study in Children was registered at clinicaltrials.gov as NCT00000459.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.