ArticleJournal of virology2010
E1A interacts with two opposing transcriptional pathways to induce quiescent cells into S phase.
Article in Journal of virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
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- Cancer immunotherapies: A hope for the uncurable?Frontiers in molecular medicine · 2023Review
- RNA helicase p68 deploys β-catenin in regulating RelA/p65 gene expression: implications in colon cancer.Journal of experimental & clinical cancer research : CR · 2019Article
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- Cell cycle S phase markers are expressed in cerebral neuron nuclei of cats infected by the Feline Panleukopenia Virus.Cell cycle (Georgetown, Tex.) · 2016Article
- The DEAD box protein p68: a crucial regulator of AKT/FOXO3a signaling axis in oncogenesis.Oncogene · 2015Article
- Exosome-mediated delivery of the intrinsic C-terminus domain of PTEN protects it from proteasomal degradation and ablates tumorigenesis.Molecular therapy : the journal of the American Society of Gene Therapy · 2015Article
- DEAD-box protein p68 is regulated by β-catenin/transcription factor 4 to maintain a positive feedback loop in control of breast cancer progression.Breast cancer research : BCR · 2014Article
- Adenovirus small E1A employs the lysine acetylases p300/CBP and tumor suppressor Rb to repress select host genes and promote productive virus infection.Cell host & microbe · 2014Article
- Genome dynamics of the human embryonic kidney 293 lineage in response to cell biology manipulations.Nature communications · 2014Article
- Tip60 degradation by adenovirus relieves transcriptional repression of viral transcriptional activator EIA.Oncogene · 2013Article
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- Reorganization of the host epigenome by a viral oncogene.Genome research · 2012Article
- Mechanism of β-catenin-mediated transcriptional regulation of epidermal growth factor receptor expression in glycogen synthase kinase 3 β-inactivated prostate cancer cells.The Journal of biological chemistry · 2012Article
- The chaperone-assisted E3 ligase C terminus of Hsc70-interacting protein (CHIP) targets PTEN for proteasomal degradation.The Journal of biological chemistry · 2012Article
- Adenovirus E1A directly targets the E2F/DP-1 complex.Journal of virology · 2011Article
- The dynamics of E1A in regulating networks and canonical pathways in quiescent cells.BMC research notes · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite data suggesting that the adenovirus E1A protein of 243 amino acids creates an S-phase environment in quiescent cells by overcoming the nucleosomal repression of E2F-regulated genes, the precise mechanisms underlying E1A's ability in this process have not yet been defined at the biochemical level. In this study, we show by kinetic analysis that E1A, as opposed to an E1A mutant failing to bind p130, can temporally eliminate corepressor complexes consisting of p130-E2F4 and HDAC1/2-mSin3B from the promoters of E2F-regulated genes in quiescent cells. Once the complexes are removed, the di-methylation of H3K9 at these promoters becomes dramatically diminished, and this in turn allows for the acetylation of H3K9/14 and the recruitment of activating E2F family members, which is then followed by the transcriptional activity of the E2F-regulated genes. Remarkably, although an E1A mutant that can no longer bind to a histone acetyltransferase (PCAF) is as capable as wild-type E1A in eliminating corepressor complexes and methyl groups from the promoters of these genes, it cannot mediate the acetylation of H3K9/14 or induce their transcription. These findings suggest that corepressors as well as coactivators are acted upon by E1A to derepress E2F-regulated genes in quiescent cells. Thus, our results highlight for the first time a functional relationship between E1A and two transcriptional pathways of differing functions for transitioning cells out of quiescence and into S phase.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.