ArticleClinical journal of the American Society of Nephrology : CJASN2010
Histopathologic features aid in predicting risk for progression of IgA nephropathy.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.
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Who cites it
48 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Risk Factors of Disease Progression in IgA Nephropathy: A Systematic Review and Meta-Analysis.Immunity, inflammation and disease · 2026Pooled it
- Association between different proportions of crescents and the progression of IgA nephropathy (IgAN): a systematic review and meta-analysis.BMC nephrology · 2024Pooled it
- Evaluation of crescent formation as a predictive marker in immunoglobulin A nephropathy: a systematic review and meta-analysis.Oncotarget · 2017Pooled it
- Validation of a renal staging system and its association with renal amyloid deposition burden in AL amyloidosis.Renal failure · 2025Article
- The predictive value and response to immunosuppressive therapy of IgA nephropathy patients with crescents in a large retrospective Chinese cohort.Clinical kidney journal · 2023Article
- Crescents proportions above 10% are associated with unfavorable kidney outcomes in IgA nephropathy patients with partial crescent formation.Renal failure · 2023Article
- Divergent manifestations and outcomes of diffuse crescentic immunoglobulin A nephropathy and pauci-immune crescentic glomerulonephritis on long-term.International urology and nephrology · 2023Article
- Evaluating the renal mild tubulointerstitial damage and renal function in IgAN patients: a comparative study based on diffusion kurtosis imaging and diffusion tensor imaging.Abdominal radiology (New York) · 2023Article
- High Renal Mast Cell Density Is Associated with Poor Prognosis in Patients with Immunoglobulin A Nephropathy.American journal of nephrology · 2023Observational
- A novel clinical-radiomic nomogram for the crescent status in IgA nephropathy.Frontiers in endocrinology · 2023Article
- Kidney biopsy chronicity grading in antineutrophil cytoplasmic antibody-associated vasculitis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022Article
- Crescents and IgA Nephropathy: A Delicate Marriage.Journal of clinical medicine · 2022Review
- Clinicopathological characteristics, risk factors and renal outcome in IgA nephropathy with crescents.Journal of nephrology · 2022Article
- The role of urine IgG in the progression of IgA nephropathy with a high proportion of global glomerulosclerosis.International urology and nephrology · 2022Article
- The Significance of Crescents on the Clinical Features and Outcomes of Primary Immunoglobin A Nephropathy.Frontiers in medicine · 2022Article
- Retrospective analysis of crescent score in clinical prognosis of IgA nephropathy.Open medicine (Warsaw, Poland) · 2022Article
- Urine β2-Microglobulin and Retinol-Binding Protein and Renal Disease Progression in IgA Nephropathy.Frontiers in medicine · 2021Article
- Glomerular C4 deposition and glomerulosclerosis predict worse renal outcomes in Chinese patients with IgA nephropathy.Renal failure · 2020Article
- The role of hypertriglyceridemia and treatment patterns in the progression of IgA nephropathy with a high proportion of global glomerulosclerosis.International urology and nephrology · 2020Article
- Crescents formations are independently associated with higher mortality in biopsy-confirmed immunoglobulin A nephropathy.PloS one · 2020Article
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Authors and funding
7 authors.
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Abstract
BACKGROUND AND
objectivesIgA nephropathy (IgAN) is the most common primary glomerular disease worldwide. Accurately identifying patients who are at risk for progressive disease is challenging. The extent to which histopathologic features improves prognostication is uncertain. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We studied a retrospective cohort with biopsy-proven IgAN in Calgary, Canada. Renal biopsies were reviewed by a nephropathologist with histopathologic data abstracted using a standardized form. The primary outcome was the composite of doubling of serum creatinine, ESRD, or death. Spline models defined significant levels of interstitial fibrosis, glomerulosclerosis, hypertension, proteinuria, and creatinine. The prognostic significances of clinical and histopathologic parameters were determined using Cox proportional hazards models.
resultsData from 146 cases were available for analysis with a median follow-up of 5.8 years. Greater than 25% interstitial fibrosis, >40% glomerular sclerosis, and a systolic BP >150 mmHg were risk thresholds. In univariable analyses, baseline creatinine, proteinuria, systolic BP, glomerular sclerosis, interstitial fibrosis, and crescentic disease were predictors of the primary outcome. In multivariable models adjusted for clinical characteristics, interstitial fibrosis (hazard ratio [HR]2.7; 95% confidence interval [CI] 1.2 to 6.0), glomerular sclerosis (HR 2.6; 95% CI 1.2 to 4.5), and crescents (HR 2.4; 95% CI 1.2 to 5.1) remained independent predictors of the primary outcome and significantly improved model fit compared with clinical characteristics alone.
conclusionsBaseline histopathologic parameters are independent predictors of adverse outcomes in IgAN even after taking into consideration clinical characteristics. Relatively small degrees of interstitial fibrosis confer an increased risk for progressive IgAN.
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