ArticleClinical journal of the American Society of Nephrology : CJASN2010
Urine microscopy is associated with severity and worsening of acute kidney injury in hospitalized patients.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04334707 (Kidney Precision Medicine Project), which is not on this map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Kidney Precision Medicine Project
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it.
- [Urine cytology - update 2013. A systematic review of recent literature].Der Urologe. Ausg. A · 2013Pooled it
- Article
- The Utility of Urine Microscopy Score for Early Detection and Prediction of Acute Kidney Injury in At-Risk Patients.Kidney360 · 2025Article
- A Holistic Approach to AKI: Integrating Clinical and Molecular Data in the Human Kidney.Seminars in nephrology · 2025Review
- Renal tubular epithelial cells as an easily accessible biomarker for diagnosing AKI post cardiac surgery.Intensive care medicine · 2025Article
- An updated approach to the evaluation of the urinary sediment.Pediatric nephrology (Berlin, Germany) · 2025Review
- Cardiorenal Syndrome in Heart Failure with Preserved Ejection Fraction: Insights into Pathophysiology and Recent Advances.Cardiorenal medicine · 2025Review
- Urinary renal tubular epithelial cells and casts as predictors of renal outcomes in patients with biopsy-proven diabetic nephropathy.Journal of nephrology · 2024Article
- Dimensions of muddy brown granular casts in patients with acute tubular injury.The American journal of the medical sciences · 2024Article
- Different Roles of Functional and Structural Renal Markers Measured at Discontinuation of Renal Replacement Therapy for Acute Kidney Injury.Blood purification · 2023Article
- Case Report: Multisystem inflammatory syndrome in children with associated proximal tubular injury.Frontiers in nephrology · 2023Article
- Concomitant Identification of Muddy Brown Granular Casts and Low Fractional Excretion of Urinary Sodium in AKI.Kidney360 · 2022Observational
- Urine Sediment Exam Provides More Diagnostic Information in AKI than Novel Urinary Biomarkers: COMMENTARY.Kidney360 · 2022Article
- Urine Sediment Exam Provides More Diagnostic Information in AKI than Novel Urinary Biomarkers: CON.Kidney360 · 2022Article
- Cardiorenal syndrome: classification, pathophysiology, diagnosis and management. Literature reviewArchivos de cardiologia de Mexico · 2022Article
- Rationale and design of the Kidney Precision Medicine Project.Kidney international · 2021Article
- Diagnostic Utility of Serial Microscopic Examination of the Urinary Sediment in Acute Kidney Injury.Kidney360 · 2021Article
- Article
- Assessment of Interobserver Reliability of Nephrologist Examination of Urine Sediment.JAMA network open · 2020Article
- Reappraising the spectrum of AKI and hepatorenal syndrome in patients with cirrhosis.Nature reviews. Nephrology · 2020Review
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6 authors.
Funding
Abstract
BACKGROUND AND
objectivesSerum creatinine concentration at the time of nephrology consultation is not necessarily indicative of the severity of acute kidney injury (AKI). Although urine microscopy is useful to differentiate AKI, its role in predicting adverse clinical outcomes has not been well described. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The relationship between urine microscopy findings at the time of nephrology consultation for AKI and clinical outcomes was evaluated prospectively. A urinary sediment scoring system was created on the basis of the number of renal tubular epithelial cells and granular casts. The primary outcome was worsening of AKI (progressing to higher AKI Network stage, dialysis, or death) during hospitalization.
resultsOf 249 patients consulted for AKI, 197 had acute tubular necrosis or prerenal AKI and were included in the analysis. At consultation, 80 (40%) had stage 1, 53 (27%) had stage 2, and 66 (33%) had stage 3 AKI. The urinary sediment combined scores were lowest in those with stage 1 and highest in stage 3 AKI. Seventy-nine patients (40%) experienced worsening of AKI from the time of consultation. The urinary scoring system was significantly associated with increased risk of worsening AKI (adjusted relative risk: 7.3; 95% confidence interval: 4.5 to 9.7 for worsening with score of > or =3 versus score of 0) and was more predictive than AKI Network stage at the time of consultation.
conclusionsThe urinary sediment score may be a useful tool to predict worsening of AKI due to either acute tubular necrosis or prerenal AKI during hospitalization.
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