ArticleThe Journal of surgical research2011
A novel role for NKT cells in cutaneous wound repair.
Article in The Journal of surgical research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Chronic Wound Healing: Research Advances from Pathological Mechanisms to Natural Herbal Active Ingredients and Material Delivery Systems.Molecules (Basel, Switzerland) · 2026Review
- Same yet different - how lymph node heterogeneity affects immune responses.Nature reviews. Immunology · 2024Review
- Role of NK Cells in Skin Wound Healing of Mice.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- NKG2D Ligand Expression Induced by Oxidative Stress Mitigates Cutaneous Ischemia-Reperfusion Injury.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2023Article
- Advances in Immunomodulatory Mechanisms of Mesenchymal Stem Cells-Derived Exosome on Immune Cells in Scar Formation.International journal of nanomedicine · 2023Review
- The role of unconventional T cells in maintaining tissue homeostasis.Seminars in immunology · 2022Review
- Bioinformatics analysis combined with experiments to verify potential autophagy genes in wound healing.Annals of translational medicine · 2022Article
- Immune Cells in Cutaneous Wound Healing: A Review of Functional Data from Animal Models.International journal of molecular sciences · 2022Review
- Keratinocytes costimulate naive human T cells via CD2: a potential target to prevent the development of proinflammatory Th1 cells in the skin.Cellular & molecular immunology · 2020Article
- Current Approaches Targeting the Wound Healing Phases to Attenuate Fibrosis and Scarring.International journal of molecular sciences · 2020Review
- Allergic Immune Diseases and the Risk of Mortality Among Patients Hospitalized for Acute Infection.Critical care medicine · 2019Article
- Immune Regulation of Skin Wound Healing: Mechanisms and Novel Therapeutic Targets.Advances in wound care · 2018Review
- Toll-Like Receptor Function in Acute Wounds.Advances in wound care · 2017Review
- The Role of Phytochemicals in the Inflammatory Phase of Wound Healing.International journal of molecular sciences · 2017Review
- The prevention of colorectal anastomotic leakage with tissue adhesives in a contaminated environment is associated with the presence of anti-inflammatory macrophages.International journal of colorectal disease · 2014Article
- The nature of innate and adaptive interleukin-17A responses in sham or bacterial inoculation.Immunology · 2012Article
- Prevention of NKT cell activation accelerates cutaneous wound closure and alters local inflammatory signals.The Journal of surgical research · 2011Article
- An improved cell isolation method for flow cytometric and functional analyses of cutaneous wound leukocytes.Journal of immunological methods · 2011Article
- Neutrophils and natural killer T cells as negative regulators of wound healing.Expert review of dermatology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Here, we report the novel observation that natural killer T (NKT) cells contribute to the cutaneous wound repair process. Using an excisional wound model in wild-type versus NKT cell-deficient mice, this report shows that when NKT cells are absent, initial wound closure is markedly accelerated. We report here for the first time that NKT cells are a significant constituent of early wound inflammation and that they regulate the local production of a key subset of neutrophil and monocyte/macrophage chemokines, as well as TGF-β1 content and collagen deposition. Together, our findings support the concept that NKT cells regulate the early inflammatory and fibroproliferative phases of nonpathologic healing wounds, positioning the NKT cell as an attractive potential therapeutic target for modulation of impaired wound healing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.