ArticleBMC cell biology2010
Nutritional control of gene expression in Drosophila larvae via TOR, Myc and a novel cis-regulatory element.
Article in BMC cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 72 citations in OpenAlex.
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- Differential Proteomics Analysis Unraveled Mechanisms ofInsects · 2022Article
- Trans-omics analysis of insulin action reveals a cell growth subnetwork which co-regulates anabolic processes.iScience · 2022Article
- TOR signalling is required for host lipid metabolic remodelling and survival following enteric infection in Drosophila.Disease models & mechanisms · 2022Article
- A low-sugar diet enhances Drosophila body size in males and females via sex-specific mechanisms.Development (Cambridge, England) · 2022Article
- The Nutrient-Responsive Molecular Chaperone Hsp90 Supports Growth and Development inFrontiers in physiology · 2021Article
- Diversification of Retinoblastoma Protein Function Associated with Cis and Trans Adaptations.Molecular biology and evolution · 2019Article
- Review
- Evolutionary responses ofFrontiers in ecology and evolution · 2018Article
- Regulation of Carbohydrate Energy Metabolism inGenetics · 2017Review
- The Hox proteins Ubx and AbdA collaborate with the transcription pausing factor M1BP to regulate gene transcription.The EMBO journal · 2017Article
- Phenotypes, antioxidant responses, and gene expression changes accompanying a sugar-only diet in Bactrocera dorsalis (Hendel) (Diptera: Tephritidae).BMC evolutionary biology · 2017Article
- Expression and RNA Interference of Ribosomal Protein L5 Gene in Nilaparvata lugens (Hemiptera: Delphacidae).Journal of insect science (Online) · 2017Article
- Review
- dMyc is required in retinal progenitors to prevent JNK-mediated retinal glial activation.PLoS genetics · 2017Article
- Can Protein Restriction Set Up T Lymphocytes Favorably For Their Activation Against Pathogens Through Myc?MOJ lymphology & phlebology · 2017Article
- Drosophila Nipped-B Mutants Model Cornelia de Lange Syndrome in Growth and Behavior.PLoS genetics · 2015Article
- Starvation-Induced Dietary Behaviour in Drosophila melanogaster Larvae and Adults.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundNutrient availability is a key determinant of eukaryotic cell growth. In unicellular organisms many signaling and transcriptional networks link nutrient availability to the expression of metabolic genes required for growth. However, less is known about the corresponding mechanisms that operate in metazoans. We used gene expression profiling to explore this issue in developing Drosophila larvae.
resultsWe found that starvation for dietary amino acids (AA's) leads to dynamic changes in transcript levels of many metabolic genes. The conserved insulin/PI3K and TOR signaling pathways mediate nutrition-dependent growth in Drosophila and other animals. We found that many AA starvation-responsive transcripts were also altered in TOR mutants. In contrast, although PI3K overexpression induced robust changes in the expression of many metabolic genes, these changes showed limited overlap with the AA starvation expression profile. We did however identify a strong overlap between genes regulated by the transcription factor, Myc, and AA starvation-responsive genes, particularly those involved in ribosome biogenesis, protein synthesis and mitochondrial function. The consensus Myc DNA binding site is enriched in promoters of these AA starvation genes, and we found that Myc overexpression could bypass dietary AA to induce expression of these genes. We also identified another sequence motif (Motif 1) enriched in the promoters of AA starvation-responsive genes. We showed that Motif 1 was both necessary and sufficient to mediate transcriptional responses to dietary AA in larvae.
conclusionsOur data suggest that many of the transcriptional effects of amino acids are mediated via signaling through the TOR pathway in Drosophila larvae. We also find that these transcriptional effects are mediated through at least two mechanisms: via the transcription factor Myc, and via the Motif 1 cis-regulatory element. These studies begin to elucidate a nutrient-responsive signaling network that controls metabolic gene transcription in Drosophila.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.