ArticleThe Plant journal : for cell and molecular biology2010
AtSIG6, a plastid sigma factor from Arabidopsis, reveals functional impact of cpCK2 phosphorylation.
Article in The Plant journal : for cell and molecular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 62 citations in OpenAlex.
- A Hanks-type bacterial kinase, PknS, directly phosphorylates the alternative sigma factor EcfK to promote resistance to protist predation.The FEBS journal · 2026Article
- Phylogenetic diversity of light-dependent phosphorylation of Thr78 in Rubisco activase.Journal of experimental botany · 2025Article
- Inorganic carbon levels regulate growth via SigC signaling cascade in cyanobacteria.The New phytologist · 2025Article
- Chloroplast gene expression: Recent advances and perspectives.Plant communications · 2023Review
- Plastid Gene Transcription: An Update on Promoters and RNA Polymerases.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Sigma factor 1 in chloroplast gene transcription and photosynthetic light acclimation.Journal of experimental botany · 2020Article
- pTAC10, an S1-domain-containing component of the transcriptionally active chromosome complex, is essential for plastid gene expression in Arabidopsis thaliana and is phosphorylated by chloroplast-targeted casein kinase II.Photosynthesis research · 2018Article
- LLM-Domain B-GATA Transcription Factors Play Multifaceted Roles in Controlling Greening in Arabidopsis.The Plant cell · 2018Article
- Opposite roles of the Arabidopsis cytokinin receptors AHK2 and AHK3 in the expression of plastid genes and genes for the plastid transcriptional machinery during senescence.Plant molecular biology · 2017Article
- Organellar Gene Expression and Acclimation of Plants to Environmental Stress.Frontiers in plant science · 2017Review
- Post-translational Modifications in Regulation of Chloroplast Function: Recent Advances.Frontiers in plant science · 2017Review
- A mutation of casein kinase 2 α4 subunit affects multiple developmental processes in Arabidopsis.Plant cell reports · 2016Article
- Phosphorylation Affects DNA-Binding of the Senescence-Regulating bZIP Transcription Factor GBF1.Plants (Basel, Switzerland) · 2015Article
- Emerging roles of protein kinase CK2 in abscisic acid signaling.Frontiers in plant science · 2015Review
- Plastid casein kinase 2 knockout reduces abscisic acid (ABA) sensitivity, thermotolerance, and expression of ABA- and heat-stress-responsive nuclear genes.Journal of experimental botany · 2014Article
- AtSIG6 and other members of the sigma gene family jointly but differentially determine plastid target gene expression in Arabidopsis thaliana.Frontiers in plant science · 2014Article
- Nuclear-encoded factors associated with the chloroplast transcription machinery of higher plants.Frontiers in plant science · 2014Review
- Article
- Evolutionary rewiring: a modified prokaryotic gene-regulatory pathway in chloroplasts.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Article
- Redox regulation of thylakoid protein kinases and photosynthetic gene expression.Antioxidants & redox signaling · 2013Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plastids contain sigma factors, i.e. gene-regulatory proteins for promoter binding and transcription initiation. Despite the physical and functional similarity shared with their prokaryotic counterparts, the plant sigma factors have distinguishing features: most notably the existence of a variable extra sequence comprising their N-terminal portions. This distinct architecture is reflected by functional differences, including phosphorylation control by organellar protein kinase(s) closely related to nucleocytosolic, rather than bacterial-type, enzymes. In particular, cpCK2, a nuclear-coded plastid-targeted casein kinase 2, has been implicated as a key component in plant sigma factor phosphorylation and transcriptional regulation (Eur. J. Biochem. 269, 2002, 3329; Planta, 219, 2004, 298). Although this notion is based mainly on biochemical evidence and in vitro systems, the recent availability of Arabidopsis sigma knock-out lines for complementation by intact and mutant sigma cDNAs has opened up new strategies for the study of transcription regulatory mechanisms in vivo. Using Arabidopsis sigma factor 6 (AtSIG6) as a paradigm, we present data suggesting that: (i) this factor is a substrate for regulatory phosphorylation by cpCK2 both in vitro and in vivo; (ii) cpCK2 phosphorylation of SIG6 occurs at multiple sites, which can widely differ in their effect on the visual and/or molecular phenotype; (iii) in vivo usage of the perhaps most critical cpCK2 site defined by Ser174 requires (pre-)phosphorylation at the n + 3 serine residue Ser177, pointing to 'pathfinder' kinase activity capable of generating a functional cpCK2 substrate site.
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