ReviewEndocrine, metabolic & immune disorders drug targets2010
Metabolic syndrome components in murine models.
Review in Endocrine, metabolic & immune disorders drug targets, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Alcohol Sensitivity as an Endophenotype of Alcohol Use Disorder: Exploring Its Translational Utility between Rodents and Humans.Brain sciences · 2020Review
- Spontaneous restoration of functional β-cell mass in obese SM/J mice.Physiological reports · 2020Article
- Genetic background and diet affect brown adipose gene coexpression networks associated with metabolic phenotypes.Physiological genomics · 2020Article
- Genome wide association analysis in a mouse advanced intercross line.Nature communications · 2018Article
- Glucose dysregulation and response to common anti-diabetic agents in the FATZO/Pco mouse.PloS one · 2017Article
- Genetics of glucose homeostasis: implications for insulin resistance and metabolic syndrome.Arteriosclerosis, thrombosis, and vascular biology · 2012Review
- Obesity-insulin targeted genes in the 3p26-25 region in human studies and LG/J and SM/J mice.Metabolism: clinical and experimental · 2012Article
- Genetic effects at pleiotropic loci are context-dependent with consequences for the maintenance of genetic variation in populations.PLoS genetics · 2011Article
- Dark matter: are mice the solution to missing heritability?Frontiers in genetics · 2011Article
- A dysregulation in CES1, APOE and other lipid metabolism-related genes is associated to cardiovascular risk factors linked to obesity.Obesity facts · 2010Article
- Genetic, epigenetic, and gene-by-diet interaction effects underlie variation in serum lipids in a LG/JxSM/J murine model.Journal of lipid research · 2010Article
- The genetics of obesity and the metabolic syndrome.Endocrine, metabolic & immune disorders drug targets · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Animal models have enriched understanding of the physiological basis of metabolic disorders and advanced identification of genetic risk factors underlying the metabolic syndrome (MetS). Murine models are especially appropriate for this type of research, and are an excellent resource not only for identifying candidate genomic regions, but also for illuminating the possible molecular mechanisms or pathways affected in individual components of MetS. In this review, we briefly discuss findings from mouse models of metabolic disorders, particularly in light of issues raised by the recent flood of human genome-wide association studies (GWAS) results. We describe how mouse models are revealing that genotype interacts with environment in important ways, indicating that the underlying genetics of MetS is highly context dependant. Further we show that epistasis, imprinting and maternal effects each contribute to the genetic architecture underlying variation in metabolic traits, and mouse models provide an opportunity to dissect these aspects of the genetic architecture that are difficult if not impossible to ascertain in humans. Finally we discuss how knowledge gained from mouse models can be used in conjunction with comparative genomic methods and bioinformatic resources to inform human MetS research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.