ArticleCNS drugs2010
Depressive disorders in restless legs syndrome: epidemiology, pathophysiology and management.
Article in CNS drugs, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 4 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Migraine and Restless Legs Syndrome: A Meta-Analysis.Journal of sleep research · 2026Pooled it
- Associations of anxiety and depression with restless leg syndrome: a systematic review and meta-analysis.Frontiers in neurology · 2024Pooled it
- Prospective study of restless legs syndrome and risk of depression in women.American journal of epidemiology · 2012Pooled it
- Prevalence of restless legs syndrome in North American and Western European populations: a systematic review.Sleep medicine · 2011Pooled it
- An Exploratory Randomized Controlled Trial of a 12-Week Yoga Versus Educational Film Program for the Management of Restless Legs Syndrome: Feasibility and Acceptability.Journal of integrative and complementary medicine · 2022Trial
- Effects of a 12-week yoga versus a 12-week educational film intervention on symptoms of restless legs syndrome and related outcomes: an exploratory randomized controlled trial.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Trial
- Trial
- Secondary Restless Legs Syndrome during psychopharmacological treatment: real-world evidence from a multinational pharmacovigilance program.The international journal of neuropsychopharmacology · 2026Article
- Development of a Stepped-Care Pathway for Managing Willis-Ekbom Disease/Restless Legs Syndrome During Pregnancy: A Best Evidence Synthesis.Nature and science of sleep · 2026Article
- Prevalence and correlates of restless leg syndrome in psychiatric outpatients in Lebanon.Scientific reports · 2025Article
- Circadian Pattern in Restless Legs Syndrome: Implications for Treatment Posology.Sleep science (Sao Paulo, Brazil) · 2024Article
- Alexithymia, Anger, Sensitivity to Mild Bodily Sensations and Personality Characteristics of Restless Legs Syndrome Patients: A Case-control Study.Turk psikiyatri dergisi = Turkish journal of psychiatry · 2024Article
- Long-term Safety, Dose Stability, and Efficacy of Opioids for Patients With Restless Legs Syndrome in the National RLS Opioid Registry.Neurology · 2023Article
- The relationship between sleep disorders, anxiety, depression, and cognitive function with restless legs syndrome (RLS) in the elderly.Sleep & breathing = Schlaf & Atmung · 2022Article
- Restless Legs Syndrome: Associated with Major Depressive Disorder and Anxiety Disorder But Not with Antidepressant Use.Psychiatry and clinical psychopharmacology · 2022Article
- Evaluation of affective temperament profile and levels of depressive symptoms and anxiety in patients with restless legs syndrome.Sleep & breathing = Schlaf & Atmung · 2022Article
- Restless legs syndrome severity in the National RLS Opioid Registry during the COVID-19 pandemic.Sleep medicine · 2022Observational
- Restless Legs Syndrome Prevalence and Clinical Correlates Among Psychiatric Inpatients: A Multicenter Study.Frontiers in psychiatry · 2022Article
- Sleep Disturbance, Sleep Disorders and Co-Morbidities in the Care of the Older Person.Medical sciences (Basel, Switzerland) · 2021Review
- Why Are Women Prone to Restless Legs Syndrome?International journal of environmental research and public health · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidemiological studies report a 2- to 4-fold risk of a depressive disorder in patients with restless legs syndrome (RLS) compared with healthy controls. The high prevalence rates of depression in RLS indicate an association between the two disorders. Severe sleep disturbance due to the nightly occurrence of RLS symptoms is a common complaint of patients with moderate or severe RLS and may substantially contribute to the emergence of depressive symptoms. Difficulty in the diagnosis of a depressive disorder in patients with RLS may arise from the overlap of symptoms in the two disorders, as sleep-related complaints are frequent both in RLS and depression. The treatment of depression in RLS has some unique aspects, as several antidepressants have been reported to trigger or worsen RLS. To date, no studies have been published regarding the course of depression in untreated and treated patients with RLS. On the other hand, the presence of co-morbid depression can have a substantial impact on the global treatment outcome. In patients with co-morbid moderate/severe depression, antidepressant therapy in parallel with or shortly after commencing RLS treatment is usually necessary. Data from recent trials with dopamine receptor agonists indicate that mild to moderate depressive symptoms are often relieved with improvement of RLS symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.