ArticleJournal of medicinal chemistry2010
Reversal agent and linker variants of reversed chloroquines: activities against Plasmodium falciparum.
Article in Journal of medicinal chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Design and syntheses of 4-aminoquinoline-thiazolidinone hybrids as anti-protozoal agents.Frontiers in chemistry · 2026Article
- Biological evaluation of novel side chain containing CQTrICh-analogs as antimalarials and their development asHeliyon · 2024Article
- Paired electrolysis enabled annulation for the quinolyl-modification of bioactive molecules.Chemical science · 2022Article
- Synthesis and Antimalarial Activity of 4-Methylaminoquinoline Compounds against Drug-Resistant Parasite.ACS omega · 2021Article
- Unsymmetrical Bisquinolines with High Potency againstMolecules (Basel, Switzerland) · 2020Article
- Zinc-Chelating Small Molecules Preferentially Accumulate and Function within Pancreatic β Cells.Cell chemical biology · 2019Article
- Quinoline-Based Hybrid Compounds with Antimalarial Activity.Molecules (Basel, Switzerland) · 2017Review
- Simplified Reversed Chloroquines To Overcome Malaria Resistance to Quinoline-Based Drugs.Antimicrobial agents and chemotherapy · 2017Article
- Anti-malarial effect of novel chloroquine derivatives as agents for the treatment of malaria.Malaria journal · 2017Article
- 3-Halo Chloroquine Derivatives Overcome Plasmodium falciparum Chloroquine Resistance Transporter-Mediated Drug Resistance in P. falciparum.Antimicrobial agents and chemotherapy · 2015Article
- Dual-functioning antimalarials that inhibit the chloroquine-resistance transporter.Future microbiology · 2013Review
- Reversed chloroquine molecules as a strategy to overcome resistance in malaria.Current topics in medicinal chemistry · 2012Review
- Antimalarial activity and mechanisms of action of two novel 4-aminoquinolines against chloroquine-resistant parasites.PloS one · 2012Article
- The Ca2+-ATPase (SERCA1) is inhibited by 4-aminoquinoline derivatives through interference with catalytic activation by Ca2+, whereas the ATPase E2 state remains functional.The Journal of biological chemistry · 2011Article
- Expanding the Antimalarial Drug Arsenal-Now, But How?Pharmaceuticals (Basel, Switzerland) · 2011Article
- A chemotype that inhibits three unrelated pathogenic targets: the botulinum neurotoxin serotype A light chain, P. falciparum malaria, and the Ebola filovirus.Journal of medicinal chemistry · 2011Article
- Synthesis, structure-activity relationship, and mode-of-action studies of antimalarial reversed chloroquine compounds.Journal of medicinal chemistry · 2010Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
We have shown that "reversed chloroquine molecules" constructed from chloroquine-like and resistance "reversal-agent"-like cores can be powerful drugs against malaria ( J. Med. Chem. 2006 , 49 , 5623 - 5625 ). Several reversed chloroquines are now presented that probe parameters governing the activities against chloroquine-resistant and chloroquine-sensitive malaria strains. The design is tolerant to linker and reversal agent changes, but a piperazinyl group adjacent to the quinoline, at least for the group of compounds studied here, may be detrimental.
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Registered trials
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