ArticleJournal of clinical laboratory analysis2010
Platelets oxidative stress in Indian patients with ischemic heart disease.
Article in Journal of clinical laboratory analysis, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- An Evaluation of the Role of Oxidative Stress in Non-Obstructive Coronary Artery Disease.Journal of cardiovascular development and disease · 2022Review
- Antiplatelet Activity of Coumarins: In Vitro Assays on COX-1.Molecules (Basel, Switzerland) · 2021Article
- Autophagy decreases alveolar macrophage apoptosis by attenuating endoplasmic reticulum stress and oxidative stress.Oncotarget · 2016Article
- Effective Components of Panax quinquefolius and Corydalis tuber Protect Myocardium through Attenuating Oxidative Stress and Endoplasmic Reticulum Stress.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- The Relationship Between Some Complete Blood Count Parameters and Myocardial Perfusion: A Scintigraphic Approach.World journal of nuclear medicineArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOxidative stress has been implicated in the development of atherosclerosis and vascular tissue injury. Both platelet activation and lipid peroxidation are known to play major role in ischemic heart disease. The purpose of this study was to investigate the status of platelets oxidative stress in Indian patients with ischemic heart disease.
methodsWe measured platelets aggregation, malonyldialdehyde (MDA), plasma-ionized Ca2+, and antioxidant enzymes, i.e., glutathione peroxidase and superoxide dismutase in healthy volunteers and patients with myocardial infarction, unstable and stable angina 40 subjects each.
resultsPlatelets aggregation, MDA, and plasma-ionized Ca(2+) have increased significantly across the patients groups compared with controls, this increase was accompanied by an overall decrease in the antioxidant enzymes activity; except for the slight increases in the glutathione peroxidase levels among the myocardial infarction patients.
conclusionsThe current results suggest that platelet lipid peroxidation as marked by increased MDA level is augmented in ischemic heart diseases. The increased oxidative stress seen in these patients was accompanied by platelet activation and impaired antioxidant enzymes activity.
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