ArticleJournal of neuro-oncology2010
Germinomas in the basal ganglia: magnetic resonance imaging classification and the prognosis.
Article in Journal of neuro-oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Basal Ganglia Germ Cell Tumors With or Without Sellar Involvement: A Long-Term Follow-Up in a Single Medical Center and a Systematic Literature Review.Frontiers in endocrinology · 2021Pooled it
- Differential dosimetric benefit of proton beam therapy over intensity modulated radiotherapy for a variety of targets in patients with intracranial germ cell tumors.Radiation oncology (London, England) · 2015Trial
- An integrated cerebrospinal fluid beta-human chorionic gonadotropin and atrophy-targeted magnetic resonance imaging strategy to reduce diagnostic delays in bilateral basal ganglia germinomas: A case series.The Journal of international medical research · 2025Article
- [Clinical analysis of 30 cases of basal ganglia germinoma in children].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2022Article
- Long-Term Outcomes and Sequelae Analysis of Intracranial Germinoma: Need to Reduce the Extended-Field Radiotherapy Volume and Dose to Minimize Late Sequelae.Cancer research and treatment · 2021Article
- Molecular Pathology and Targeted Therapies for Personalized Management of Central Nervous System Germinoma.Journal of personalized medicine · 2021Review
- Imaging diagnosis of basal ganglia germ cell tumors: subtype features subtype imaging features of GCTs.The British journal of radiology · 2021Article
- Imaging of brain tumors in children: the basics-a narrative review.Translational pediatrics · 2021Review
- Bilateral lesions of the basal ganglia and thalami (central grey matter)-pictorial review.Neuroradiology · 2020Review
- A single-center study of treatment outcomes of pediatric basal ganglia germinoma in Taiwan.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Treatment outcomes based on radiation therapy fields for bifocal germinoma: Synchronous or disseminated disease?PloS one · 2019Article
- Neurocognitive function, performance status, and quality of life in pediatric intracranial germ cell tumor survivors.Journal of neuro-oncology · 2019Article
- Thalamic germinoma: a challenging diagnosis, case report and literature review.Journal of surgical case reports · 2018Article
- Intracranial Germ Cell Tumor in the Molecular Era.Journal of Korean Neurosurgical Society · 2018Review
- T2*-based MR imaging (gradient echo or susceptibility-weighted imaging) in midline and off-midline intracranial germ cell tumors: a pilot study.Neuroradiology · 2018Article
- MRI features of pediatric intracranial germ cell tumor subtypes.Journal of neuro-oncology · 2017Article
- Article
- Early imaging findings in germ cell tumors arising from the basal ganglia.Pediatric radiology · 2016Article
- Accelerated Unilateral Radiographic Huntingtonian Changes Following Neoadjuvant Chemotherapy for a Nongerminomatous Germ Cell Tumor Leading to Identification of Occult Disease in the Dorsal Striatum.Journal of pediatric hematology/oncology · 2016Article
- Germinoma in the bilateral basal ganglia presented with cognitive deterioration.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Germinoma in the basal ganglia (BG) is notorious for its diagnostic difficulty. Clinical and radiological features of this disease are quite diverse, but have not been well characterized with respect to prognosis. We retrospectively reviewed the clinical course and treatment outcomes of 17 patients with a BG germinoma. The initial magnetic resonance imaging (MRI) features were classified. Clinical features and treatment outcomes were then analyzed with this classification scheme. A Type 1 lesion was defined as a subtle lesion with faint or no contrast enhancement (six patients). Type 2, 3, and 4 lesions were defined as contrast-enhancing lesions and were differentiated by the lesion size and the presence of subependymal seeding (11 patients). Type 1 lesions were distinct from the other lesions. Patients with a Type 1 lesion had a significantly longer time from the initial MRI to diagnosis than patients with Type 2, 3, and 4 lesions (P = 0.012). The actuarial progression-free survival and overall survival of patients 5 years after diagnosis were 66 and 77%, respectively. The presence of a Type 1 lesion (P = 0.004), a longer time delay in the diagnosis (P = 0.038), and radiation therapy without complete ventricular coverage (P = 0.010) were significantly associated with tumor progression. Profound motor deficits at diagnosis were associated with deterioration in motor function after tumor remission (P = 0.035). Early diagnosis of BG germinomas could affect the ability to control a tumor and neurological outcomes. In particular, high clinical suspicion and active diagnostic procedures are recommended. For optimal treatment, radiation fields should include entire ventricles even if there is no subependymal seeding.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.