ArticleCancer causes & control : CCC2010
Human papillomavirus is not associated with colorectal cancer in a large international study.
Article in Cancer causes & control : CCC, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Human papillomavirus and colorectal cancer.Medical oncology (Northwood, London, England) · 2018Pooled it
- Mendelian randomization analyses support causal relationships between HPV infection and colorectal cancer.Discover oncology · 2024Article
- Immune landscape and oncobiota in HPV-Associated Colorectal Cancer: an explorative study.Clinical and experimental medicine · 2023Article
- Evaluation of human papillomavirus DNA in colorectal cancer and adjacent mucosal tissue samples.Infectious agents and cancer · 2023Article
- Incidence and association of high-risk HPVs and EBV in patients with advanced stages of colorectal cancer from Qatar.Human vaccines & immunotherapeutics · 2023Article
- Human Papilloma Virus: An Unraveled Enigma of Universal Burden of Malignancies.Pathogens (Basel, Switzerland) · 2023Review
- Colorectal cancer and gut viruses: a visualized analysis based on CiteSpace knowledge graph.Frontiers in microbiology · 2023Article
- EBV and HPV Infections in Colorectal Cancer and Their Effect on P53 and P16 Protein Expression.International journal of molecular and cellular medicine · 2023Article
- Human Papillomaviruses-Related Cancers: An Update on the Presence and Prevention Strategies in the Middle East and North African Regions.Pathogens (Basel, Switzerland) · 2022Review
- Dynamic impact of virome on colitis and colorectal cancer: Immunity, inflammation, prevention and treatment.Seminars in cancer biology · 2022Review
- Human Papillomavirus Infection and Oropharyngeal and Gastrointestinal Cancers: A Causal Relationship?Diseases (Basel, Switzerland) · 2022Review
- Article
- Human Papillomavirus and Risk of Colorectal Cancer: An Analysis of Nationwide Claims Data.Medicina (Kaunas, Lithuania) · 2022Article
- Viruses in colorectal cancer.Molecular oncology · 2022Review
- Viruses in Cancers of the Digestive System: Active Contributors or Idle Bystanders?International journal of molecular sciences · 2020Review
- Human Papillomaviruses and Epstein-Barr Virus Interactions in Colorectal Cancer: A Brief Review.Pathogens (Basel, Switzerland) · 2020Review
- Human papillomavirus (HPV) 16 infection is not detected in rectal carcinoma.Infectious agents and cancer · 2020Article
- Article
- Does human papillomavirus cause human colorectal cancer? Applying Bradford Hill criteria postulates.Ecancermedicalscience · 2020Article
- Gut microbiota in colorectal cancer: mechanisms of action and clinical applications.Nature reviews. Gastroenterology & hepatology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 4 countries.
Funding
Abstract
objective of the studyRecent publications have reported an association between colon cancer and human papillomaviruses (HPV), suggesting that HPV infection of the colonic mucosa may contribute to the development of colorectal cancer.
methodsThe GP5+/GP6+ PCR reverse line blot method was used for detection of 37 types of human papillomavirus (HPV) in DNA from paraffin-embedded or frozen tissues from patients with colorectal cancer (n = 279) and normal adjacent tissue (n = 30) in three different study populations, including samples from the United States (n = 73), Israel (n = 106) and Spain (n = 100). Additionally, SPF10 PCR was run on all samples (n = 279) and the Innogenetics INNO-LiPA assay was performed on a subset of samples (n = 15).
resultsAll samples were negative for all types of HPV using both the GP5+/GP6+ PCR reverse line blot method and the SPF10 INNO-LiPA method.
conclusionsWe conclude that HPV types associated with malignant transformation do not meaningfully contribute to adenocarcinoma of the colon.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.