ArticleJournal of bone and mineral metabolism2010
Adiposity and genetic admixture, but not race/ethnicity, influence bone mineral content in peripubertal children.
Article in Journal of bone and mineral metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Review
- Relative Skeletal Maturation and Population Ancestry in Nonobese Children and Adolescents.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- The role of racial genetic admixture with endometrial cancer outcomes: An NRG Oncology/Gynecologic Oncology Group study.Gynecologic oncology · 2016Article
- Vitamin D Associations With Renal, Bone, and Cardiovascular Phenotypes: African American-Diabetes Heart Study.The Journal of clinical endocrinology and metabolism · 2015Article
- Vitamin D metabolites and bone mineral density: The multi-ethnic study of atherosclerosis.Bone · 2015Article
- Vitamin D and calcium-sensing receptor polymorphisms differentially associate with resting energy expenditure in peripubertal children.Journal of bone and mineral metabolism · 2013Article
- Adequate vitamin D status and adiposity contribute to bone health in peripubertal nonobese children.Journal of bone and mineral metabolism · 2013Article
- Getting to the height of the matter: the relationship between stature and adiposity in pre-pubertal children.Ethnicity & disease · 2013Article
- Genetic admixture and obesity: recent perspectives and future applications.Human heredity · 2013Review
- Calcium homeostasis may influence resting energy expenditure with effects most apparent in early pubertal girls.Acta paediatrica (Oslo, Norway : 1992) · 2012Article
- Biogeographic ancestry, self-identified race, and admixture-phenotype associations in the Heart SCORE Study.American journal of epidemiology · 2012Article
- Parental feeding practices and socioeconomic status are associated with child adiposity in a multi-ethnic sample of children.Appetite · 2012Article
- Beyond thriftiness: independent and interactive effects of genetic and dietary factors on variations in fat deposition and distribution across populations.American journal of physical anthropology · 2011Article
- African genetic admixture is associated with body composition and fat distribution in a cross-sectional study of children.International journal of obesity (2005) · 2011Article
- Does fat fuel the fire: independent and interactive effects of genetic, physiological, and environmental factors on variations in fat deposition and distribution across populations.Journal of pediatric endocrinology & metabolism : JPEM · 2010Article
- The role of European genetic admixture in the etiology of the insulin resistance syndrome in children: are the effects mediated by fat accumulation?The Journal of pediatrics · 2010Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The effect of fat mass on bone mineral content (BMC) in children is not clear, particularly when considering a diverse population. Ancestral genetic admixture may be an approach to accurately identify population differences in BMC. Our objective was to evaluate the relationships between self-reported race/ethnicity, genetic admixture, and fat mass on BMC in a multiethnic sample of children (n = 270), taking into account dietary and physical activity variables. Ancestral genetic admixture was estimated using 140 ancestry informative markers, body composition by dual-energy X-ray absorptiometry, diet by 24-h recall, and physical activity by accelerometry. Multiple linear regression examined the relationships between race/ethnicity or genetic admixture and percent fat on BMC. Additional analyses were conducted to examine the relationship between race/ethnicity or genetic admixture and BMC stratified by body fat percentage cutpoints. In regression models, there was no association between race/ethnicity and BMC. In contrast, African admixture (AFADM) was positively associated with BMC, American Indian admixture (AMINADM) was inversely associated with BMC, and there was no association between European admixture (EUADM) and BMC. When stratified by percent fat group, high body fat percentage was inversely associated with BMC with EUADM and AMINADM (P = 0.03 and P = 0.02, respectively) and positively associated with AFADM (P < 0.001). Diet and physical activity were not related to BMC in this sample. Our findings suggest that genetic admixture and percent body fat, but not race/ethnicity, diet, or physical activity, influence BMC in our sample of peripubertal children. Further, there is a differential impact of percent fat on BMC that may be mediated by genetic admixture.
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Registered trials
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