Evidence map›Paper›PMID 20087432›Full record

ArticleNuclear receptor signaling2009

Nuclear hormone receptor architecture - form and dynamics: The 2009 FASEB Summer Conference on Dynamic Structure of the Nuclear Hormone Receptors.

Iain J McEwan, Ann M Nardulli

Abstract readConference Proceedings
In one paragraph

Article in Nuclear receptor signaling, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Iain J McEwanMolecular and Cellular Endocrinology, School of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK. iain.mcewan@abdn.ac.uk
Ann M Nardulli

Funding

INTERACTION OF THE ESTROGEN RECEPTOR WITH DNAR01DK053884 · NIDDK · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI NARDULLI, ANN · 1999 to 2014
$4.0M
Dynamic Structure of the Nuclear Hormone ReceptorsR13DK083798 · NIDDK · FEDERATION OF AMER SOC FOR EXPER BIOLOGY · PI NARDULLI, ANN · 2009 to 2009
$15k
Medical Research Council MC_U127688476NIDDK NIH HHS R01 DK053884NIDDK NIH HHS R13 DK083798NIDDK NIH HHS R13DK083798
6 · The paper itself

Abstract

Nuclear hormone receptors (NHRs) represent a large and diverse family of ligand-activated transcription factors involved in regulating development, metabolic homeostasis, salt balance and reproductive health. The ligands for these receptors are typically small hydrophobic molecules such as steroid hormones, thyroid hormone, vitamin D3 and fatty acid derivatives. The first NHR structural information appeared approximately 20 years ago with the solution and crystal structures of the DNA binding domains and was followed by the structure of the agonist and antagonist bound ligand binding domains of different NHR members. Interestingly, in addition to these defined structural features, it has become clear that NHRs also possess significant structural plasticity. Thus, the dynamic structure of the NHRs was the topic of a recent stimulating and informative FASEB Summer Research Conference held in Vermont.

Indexed as

AnimalsCo-Repressor ProteinsDNADNA-Binding ProteinsGene Expression RegulationHumansLigandsNeoplasmsReceptors, Cytoplasmic and NuclearReceptors, Thyroid HormoneCo-Repressor ProteinsDNADNA-Binding ProteinsLigandsReceptors, Cytoplasmic and NuclearReceptors, Thyroid Hormone

Identifiers

PMID20087432
PMCPMC2807637

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.