ReviewNuclear receptor signaling2009
Hairless is a nuclear receptor corepressor essential for skin function.
Review in Nuclear receptor signaling, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- The Histone Demethylase HR Suppresses Breast Cancer Development through Enhanced CELF2 Tumor Suppressor Activity.Cancers · 2022Article
- Novel rhino-like SHJHZoological research · 2021Article
- Hairless regulates heterochromatin maintenance and muscle stem cell function as a histone demethylase antagonist.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Control of Breast Cancer Pathogenesis by Histone Methylation and the Hairless Histone Demethylase.Endocrinology · 2021Review
- Vitamin D-vitamin D receptor system down-regulates expression of uncoupling proteins in brown adipocyte through interaction with Hairless protein.Bioscience reports · 2020Article
- Transgenic mice display hair loss and regrowth overexpressing mutant Hr gene.Experimental animals · 2017Article
- Naked but not Hairless: the pitfalls of analyses of molecular adaptation based on few genome sequence comparisons.Genome biology and evolution · 2015Article
- Hair follicle disruption facilitates pathogenesis to UVB-induced cutaneous inflammation and basal cell carcinoma development in Ptch(+/-) mice.The American journal of pathology · 2014Article
- Hairless is a histone H3K9 demethylase.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Characterization of hairless (Hr) and FGF5 genes provides insights into the molecular basis of hair loss in cetaceans.BMC evolutionary biology · 2013Article
- Hairless promotes PPARγ expression and is required for white adipogenesis.EMBO reports · 2012Article
- Chromatin as an oxygen sensor and active player in the hypoxia response.Cellular signalling · 2012Review
- Loss of hairless confers susceptibility to UVB-induced tumorigenesis via disruption of NF-kappaB signaling.PloS one · 2012Article
- TNIP1 is a corepressor of agonist-bound PPARs.Archives of biochemistry and biophysics · 2011Article
- Article
- Molecular evolution of HR, a gene that regulates the postnatal cycle of the hair follicle.Scientific reports · 2011Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
The activity of nuclear receptors is modulated by numerous coregulatory factors. Corepressors can either mediate the ability of nuclear receptors to repress transcription, or can inhibit transactivation by nuclear receptors. As we learn more about the mechanisms of transcriptional repression, the importance of repression by nuclear receptors in development and disease has become clear. The protein encoded by the mammalian Hairless (Hr) gene was shown to be a corepressor by virtue of its functional similarity to the well-established corepressors N-CoR and SMRT. Mutation of the Hr gene results in congenital hair loss in both mice and men. Investigation of Hairless function both in vitro and in mouse models in vivo has revealed a critical role in maintaining skin and hair by regulating the differentiation of epithelial stem cells, as well as a putative role in regulating gene expression via chromatin remodeling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.