ArticleEuropean journal of human genetics : EJHG2010
Tag-SNP analysis of the GFI1-EVI5-RPL5-FAM69 risk locus for multiple sclerosis.
Article in European journal of human genetics : EJHG, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Drosophila Evi5 is a critical regulator of intracellular iron transport via transferrin and ferritin interactions.Nature communications · 2024Article
- Regulation of secretory pathway kinase or kinase-like proteins in human cancers.Frontiers in immunology · 2023Review
- Genetics and functional genomics of multiple sclerosis.Seminars in immunopathology · 2022Review
- Adaptive Fisher method detects dense and sparse signals in association analysis of SNV sets.BMC medical genomics · 2020Article
- Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility.Science (New York, N.Y.) · 2019Article
- The Genetics of Multiple Sclerosis: From 0 to 200 in 50 Years.Trends in genetics : TIG · 2017Review
- Association of EVI5 rs11808092, CD58 rs2300747, and CIITA rs3087456 polymorphisms with multiple sclerosis risk: A meta-analysis.Meta gene · 2016Article
- A non-synonymous single-nucleotide polymorphism associated with multiple sclerosis risk affects the EVI5 interactome.Human molecular genetics · 2015Article
- Susceptibility Genes for Multiple Sclerosis Identified in a Gene-Based Genome-Wide Association Study.Journal of clinical neurology (Seoul, Korea) · 2015Article
- SPOCK3, a risk gene for adult ADHD and personality disorders.European archives of psychiatry and clinical neuroscience · 2014Article
- Association of interleukin 7 receptor gene polymorphism rs6897932 with multiple sclerosis patients in Khuzestan.Iranian journal of neurology · 2014Article
- A novel predicted calcium-regulated kinase family implicated in neurological disorders.PloS one · 2013Article
- Replication study of multiple sclerosis (MS) susceptibility alleles and correlation of DNA-variants with disease features in a cohort of Austrian MS patients.Neurogenetics · 2012Article
- Genome-wide CTCF distribution in vertebrates defines equivalent sites that aid the identification of disease-associated genes.Nature structural & molecular biology · 2011Article
- Gfi1-cells and circuits: unraveling transcriptional networks of development and disease.Current opinion in hematology · 2010Review
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A recent genome-wide association study conducted by the International Multiple Sclerosis Genetic Consortium (IMSGC) identified, among others, a number of putative multiple sclerosis (MS) susceptibility variants at position 1p22. Twenty-one SNPs positively associated with MS were located at the GFI-EVI5-RPL5-FAM69A locus. In this study, we performed an analysis and fine mapping of this locus, genotyping eight Tag-SNPs in 732 MS patients and 974 controls from Spain. We observed an association with MS in three of eight Tag-SNPs: rs11804321 (P=0.008, OR=1.29; 95% CI=1.08-1.54), rs11808092 (P=0.048, OR=1.19; 95% CI=1.03-1.39) and rs6680578 (P=0.0082, OR=1.23; 95% CI=1.07-1.41). After correcting for multiple comparisons and using logistic regression analysis to test the addition of each SNP to the most associated SNPs, we observed that rs11804321 alone was sufficient to model the association. This Tag-SNP captures two SNPs in complete linkage disequilibrium (r(2)=1), both located within the 17th intron of the EVI5 gene. Our findings agree with the corresponding data of the recent IMSGC study and present new genetic evidence that points to EVI5 as a factor of susceptibility to MS.
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