ArticleEuropean journal of human genetics : EJHG2010
Association between genes on chromosome 4p16 and non-syndromic oral clefts in four populations.
Article in European journal of human genetics : EJHG, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- YANK2 activated by Fyn promotes glioma tumorigenesis via the mTOR-independent p70S6K activation pathway.Scientific reports · 2024Article
- Genome-wide analysis of copy-number variation in humans with cleft lip and/or cleft palate identifies COBLL1, RIC1, and ARHGEF38 as clefting genes.American journal of human genetics · 2023Article
- Wavelet Screening identifies regions highly enriched for differentially methylated loci for orofacial clefts.NAR genomics and bioinformatics · 2021Article
- Msx1 loss suppresses formation of the ectopic crypts developed in the Apc-deficient small intestinal epithelium.Scientific reports · 2019Article
- Application of high-resolution array platform for genome-wide copy number variation analysis in patients with nonsyndromic cleft lip and palate.Journal of clinical laboratory analysis · 2018Article
- Non-syndromic Cleft Lip and Palate Polymorphisms Affect Normal Lip Morphology.Frontiers in genetics · 2018Article
- Deleterious coding variants in multi-case families with non-syndromic cleft lip and/or palate phenotypes.Scientific reports · 2016Article
- Identification of susceptibility genes in non-syndromic cleft lip with or without cleft palate using whole-exome sequencing.Medicina oral, patologia oral y cirugia bucal · 2015Article
- Di-ethylhexylphthalate (DEHP) modulates cell invasion, migration and anchorage independent growth through targeting S100P in LN-229 glioblastoma cells.International journal of environmental research and public health · 2014Article
- Clinical relevance of breast cancer-related genes as potential biomarkers for oral squamous cell carcinoma.BMC cancer · 2014Article
- Article
- MSX1 gene and nonsyndromic oral clefts in a Southern Brazilian population.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2013Article
- Calcium-binding protein S100P and cancer: mechanisms and clinical relevance.Journal of cancer research and clinical oncology · 2012Review
- Is Chromosome 15q13.3 Duplication Involving CHRNA7 Associated With Oral Clefts?Child neurology openArticle
Corrections and comments
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Authors and funding
22 authors at 11 institutions in 7 countries.
Funding
Abstract
Isolated cleft lip with or without cleft palate and cleft palate are among the most common human birth defects. Several candidate gene studies on MSX1 have shown significant association between markers in MSX1 and risk of oral clefts, and re-sequencing studies have identified multiple mutations in MSX1 in a small minority of cases, which may account for 1-2% of all isolated oral clefts cases. We explored the 2-Mb region around MSX1, using a marker map of 393 single nucleotide polymorphisms (SNPs) in 297 cleft lip, with or without cleft palate, case-parent trios and 84 cleft palate trios from Maryland, Taiwan, Singapore, and Korea. Both individual markers and haplotypes of two to five SNPs showed several regions yielding statistical evidence for linkage and disequilibrium. Two genes (STK32B and EVC) yielded consistent evidence from cleft lip, with or without cleft palate, trios in all four populations. These two genes plus EVC2 also yielded suggestive evidence for linkage and disequilibrium among cleft palate trios. This analysis suggests that several genes, not just MSX1, in this region may influence risk of oral clefts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.