ArticleEuropean journal of clinical nutrition2010
Serum folate and homocysteine and depressive symptoms among Japanese men and women.
Article in European journal of clinical nutrition, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Depression and lifestyle: Focusing on nutrition, exercise, and their possible relevance to molecular mechanisms.Psychiatry and clinical neurosciences · 2023Pooled it
- The relationship between homocysteine and post-stroke depression in patients with spontaneous intracerebral hemorrhage.BMC neurology · 2026Article
- Unlocking the Secrets: Exploring the Biochemical Correlates of Suicidal Thoughts and Behaviors in Adults with Autism Spectrum Conditions.Biomedicines · 2023Article
- Associations between healthy Japanese dietary patterns and depression in Japanese women.Public health nutrition · 2021Article
- Associations between dietary intake of B-vitamins and psychological disorders among Iranian women: a cross-sectional study.Public health nutrition · 2021Article
- Plasma homocysteine concentrations and depression: A twin study.Journal of affective disorders reports · 2021Article
- Influence of genetic polymorphisms in homocysteine and lipid metabolism systems on antidepressant drug response.BMC psychiatry · 2020Article
- Intakes of folate, vitamin B6 and B12 and risk of depression in community-dwelling older adults: the Quebec Longitudinal Study on Nutrition and Aging.European journal of clinical nutrition · 2016Article
- Coffee consumption is inversely associated with depressive status in Japanese patients with type 2 diabetes.Journal of clinical biochemistry and nutrition · 2014Article
- Association of serum leptin and ghrelin with depressive symptoms in a Japanese working population: a cross-sectional study.BMC psychiatry · 2014Article
- Serum pyridoxal concentrations and depressive symptoms among Japanese adults: results from a prospective study.European journal of clinical nutrition · 2013Article
- Antioxidant status and its association with elevated depressive symptoms among US adults: National Health and Nutrition Examination Surveys 2005-6.The British journal of nutrition · 2013Article
- Dietary treatment options for depression among diabetic patient, focusing on macronutrients.Journal of diabetes research · 2013Review
- Nutritional epidemiology of type 2 diabetes and depressive symptoms.Journal of epidemiology · 2013Review
- Folate intake and depressive symptoms in Japanese workers considering SES and job stress factors: J-HOPE study.BMC psychiatry · 2012Article
- Use of folic acid and vitamin supplementation among adults with depression and anxiety: a cross-sectional, population-based survey.Nutrition journal · 2011Article
- Serum 25-hydroxyvitamin d concentrations and season-specific correlates in Japanese adults.Journal of epidemiology · 2011Article
- Serum folate, vitamin B-12, and homocysteine and their association with depressive symptoms among U.S. adults.Psychosomatic medicine · 2010Article
- Fish consumption and omega-3 polyunsaturated fatty acids in relation to depressive episodes: a cross-sectional analysis.PloS one · 2010Article
- Elevated homocysteine and depression outcomes in patients with comorbid medical conditions in rural primary care.International journal of noncommunicable diseasesArticle
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesFolate and homocysteine have been implicated to have a role in depression. However, results of epidemiologic studies on this issue have been inconsistent. The objective of this study was to clarify the association between serum folate and homocysteine concentrations and depressive symptoms in Japanese adults. SUBJECTS/
methodsWe analyzed cross-sectional data for 530 municipal employees (313 men and 217 women), aged 21-67 years, who participated in a health survey at the time of periodic checkup. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale. Logistic regression analysis was used to estimate odds ratios of depressive symptoms (CES-D scale scores of >or=16) with adjustment for potential confounding variables.
resultsIn total, 113 men (36.1%) and 79 women (36.4%) had depressive symptoms. A higher serum folate was associated with a decreased prevalence of depressive symptoms in men. The multivariate-adjusted odds ratios (95% confidence interval) of depressive symptoms for the lowest to highest quartiles of serum folate were 1.00 (reference), 0.53 (0.27-1.03), 0.33 (0.16-0.68) and 0.51 (0.25-1.03), respectively (trend P=0.03). Furthermore, the data suggested a positive association between serum homocysteine and depressive symptoms in men (trend P=0.06). In women, neither folate nor homocysteine was associated with depressive symptoms.
conclusionsLow serum folate may be related to an increased prevalence of depressive symptoms in Japanese men.
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