ArticleBritish journal of cancer2010
IE63-specific T-cell responses associate with control of subclinical varicella zoster virus reactivation in individuals with malignancies.
Article in British journal of cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Varicella-zoster virus-derived major histocompatibility complex class I-restricted peptide affinity is a determining factor in the HLA risk profile for the development of postherpetic neuralgia.Journal of virology · 2015Pooled it
- Immunogenicity of Varicella Zoster Virus DNA Vaccines Encoding Glycoprotein E and Immediate Early Protein 63 in Mice.Viruses · 2022Article
- A Simple-to-PerformFrontiers in immunology · 2022Article
- Varicella zoster virus (VZV)-specific immunity and subclinical VZV reactivation in patients with autoimmune diseases.The Korean journal of internal medicine · 2021Article
- Molecular mechanisms of human herpes viruses inferring with host immune surveillance.Journal for immunotherapy of cancer · 2020Review
- Varicella-Zoster Virus-Specific Cellular Immune Responses to the Live Attenuated Zoster Vaccine in Young and Older Adults.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Herpes zoster and the search for an effective vaccine.Clinical and experimental immunology · 2017Review
- Expansion of highly activated invariant natural killer T cells with altered phenotype in acute dengue infection.Clinical and experimental immunology · 2016Article
- The VZV/IE63-specific T cell response prevents herpes zoster in fingolimod-treated patients.Neurology(R) neuroimmunology & neuroinflammation · 2016Article
- Article
- Functionality of dengue virus specific memory T cell responses in individuals who were hospitalized or who had mild or subclinical dengue infection.PLoS neglected tropical diseases · 2015Article
- Effector and Central Memory Poly-Functional CD4(+) and CD8(+) T Cells are Boosted upon ZOSTAVAX(®) Vaccination.Frontiers in immunology · 2015Article
- Development of an IFN-γ ELISpot assay to assess varicella-zoster virus-specific cell-mediated immunity following umbilical cord blood transplantation.Journal of visualized experiments : JoVE · 2014Article
- Influence of frequent infectious exposures on general and varicella-zoster virus-specific immune responses in pediatricians.Clinical and vaccine immunology : CVI · 2014Article
- Suppression of virus specific immune responses by IL-10 in acute dengue infection.PLoS neglected tropical diseases · 2013Article
- Cellular and cytokine correlates of severe dengue infection.PloS one · 2012Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundReactivation of the varicella zoster virus (VZV) is more common in patients with malignancies; however, the molecular and cellular mechanisms underlying this susceptibility are unclear.
methodsUsing ex vivo interferon-gamma ELISpot assays, we set out to analyse VZV-specific immune responses in a large cohort of patients with malignancies.
resultsWe observed that patients with malignancies had impaired VZV-specific T-cell responses, particularly in those with haematological malignancies and breast carcinoma. Immediate-early protein 63 (IE63)-specific T-cell responses were significantly impaired in those with subclinical VZV re-activation.
conclusionsOur results suggest that T-cell responses to IE63 are important in controlling VZV replication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.