ArticleMolecular systems biology2010
Control of ATP homeostasis during the respiro-fermentative transition in yeast.
Article in Molecular systems biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Article
- A Dive Into Yeast's Sugar Diet-Comparing the Metabolic Response of Glucose, Fructose, Sucrose, and Maltose Under Dynamic Feast/Famine Conditions.Biotechnology and bioengineering · 2025Article
- Assessing the physiological properties of baker's yeast based on single-cell Raman spectrum technology.Synthetic and systems biotechnology · 2025Article
- Cellular energy regulates mRNA degradation in a codon-specific manner.Molecular systems biology · 2024Article
- Single nucleotide polymorphisms associated with wine fermentation and adaptation to nitrogen limitation in wild and domesticated yeast strains.Biological research · 2023Article
- Article
- Monitoring Intracellular Metabolite Dynamics inMetabolites · 2022Article
- Transcriptomic and metabolomic analysis reveals genes related to stress tolerance in high gravity brewing.World journal of microbiology & biotechnology · 2022Article
- Kinetic Modeling ofMetabolites · 2022Review
- GTP binding to translation factor eIF2B stimulates its guanine nucleotide exchange activity.iScience · 2021Article
- Characterization of the impact of GMP/GDP synthesis inhibition on replicative lifespan extension in yeast.Current genetics · 2020Article
- An Improved ATP FRET Sensor For Yeast Shows Heterogeneity During Nutrient Transitions.ACS sensors · 2020Article
- Substrate inhibition imposes fitness penalty at high protein stability.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
- Enhanced acetic acid stress tolerance and ethanol production inBiotechnology for biofuels · 2019Article
- Discovery and Functional Characterization of a Yeast Sugar Alcohol Phosphatase.ACS chemical biology · 2018Article
- Trehalose-6-phosphate promotes fermentation and glucose repression inMicrobial cell (Graz, Austria) · 2018Article
- Neural Signaling Metabolites May Modulate Energy Use in Hibernation.Neurochemical research · 2017Review
- Recent insights into the function of autophagy in cancer.Genes & development · 2016Review
- Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells.Genes & development · 2016Article
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Authors and funding
7 authors.
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Abstract
Respiring Saccharomyces cerevisiae cells respond to a sudden increase in glucose concentration by a pronounced drop of their adenine nucleotide content ([ATP]+[ADP]+[AMP]=[AXP]). The unknown fate of 'lost' AXP nucleotides represented a long-standing problem for the understanding of the yeast's physiological response to changing growth conditions. Transient accumulation of the purine salvage pathway intermediate, inosine, accounted for the apparent loss of adenine nucleotides. Conversion of AXPs into inosine was facilitated by AMP deaminase, Amd1, and IMP-specific 5'-nucleotidase, Isn1. Inosine recycling into the AXP pool was facilitated by purine nucleoside phosphorylase, Pnp1, and joint action of the phosphoribosyltransferases, Hpt1 and Xpt1. Analysis of changes in 24 intracellular metabolite pools during the respiro-fermentative growth transition in wild-type, amd1, isn1, and pnp1 strains revealed that only the amd1 mutant exhibited significant deviations from the wild-type behavior. Moreover, mutants that were blocked in inosine production exhibited delayed growth acceleration after glucose addition. It is proposed that interconversion of adenine nucleotides and inosine facilitates rapid and energy-cost efficient adaptation of the AXP pool size to changing environmental conditions.
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