ReviewCurrent opinion in pediatrics2010
Genetics of bronchopulmonary dysplasia in the age of genomics.
Review in Current opinion in pediatrics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Bronchopulmonary dysplasia and wnt pathway-associated single nucleotide polymorphisms.Pediatric research · 2022Trial
- Analysis of the Role of Gene Variants in Matrix Metalloproteinases and Their Tissue Inhibitors in Bronchopulmonary Dysplasia (BPD): A Study in the Polish Population.Current issues in molecular biology · 2025Article
- Oxygen and mechanical stretch in the developing lung: risk factors for neonatal and pediatric lung disease.Frontiers in medicine · 2023Review
- Insulin-like growth factor-1: A potential target for bronchopulmonary dysplasia treatment (Review).Experimental and therapeutic medicine · 2022Review
- Hydrogen sulfide, oxygen, and calcium regulation in developing human airway smooth muscle.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Article
- Angiogenesis-related genes may be a more important factor than matrix metalloproteinases in bronchopulmonary dysplasia development.Oncotarget · 2017Article
- [Expression of long non-coding RNA NANCI in lung tissues of neonatal mice with hyperoxia-induced lung injury and its regulatory effect on NKX2.1].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017Article
- Recurrent copy number variants associated with bronchopulmonary dysplasia.Pediatric research · 2016Article
- Biomarkers for Bronchopulmonary Dysplasia in the Preterm Infant.Frontiers in pediatrics · 2016Review
- Association of vitamin D binding protein polymorphisms with bronchopulmonary dysplasia: a case-control study of gc globulin and bronchopulmonary dysplasia.Journal of perinatology : official journal of the California Perinatal Association · 2015Article
- Animal models of bronchopulmonary dysplasia. The term mouse models.American journal of physiology. Lung cellular and molecular physiology · 2014Review
- A study of genes encoding cytokines (IL6, IL10, TNF), cytokine receptors (IL6R, IL6ST), and glucocorticoid receptor (NR3C1) and susceptibility to bronchopulmonary dysplasia.BMC medical genetics · 2014Article
- Epidemiology of bronchopulmonary dysplasia.Birth defects research. Part A, Clinical and molecular teratology · 2014Review
- A 24-year-old woman with episodes of shortness of breath, cough and wheezing.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2013Article
- Toll-like receptor genetic variants are associated with Gram-negative infections in VLBW infants.Journal of perinatology : official journal of the California Perinatal Association · 2013Article
- Single nucleotide polymorphism in toll-like receptor 6 is associated with a decreased risk for ureaplasma respiratory tract colonization and bronchopulmonary dysplasia in preterm infants.The Pediatric infectious disease journal · 2013Article
- Article
- Histological chorioamnionitis and bronchopulmonary dysplasia: a retrospective cohort study.Journal of perinatology : official journal of the California Perinatal Association · 2013Article
- Chorioamnionitis and lung injury in preterm newborns.Critical care research and practice · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
purpose of reviewAccording to recent evidence, susceptibility to bronchopulmonary dysplasia (BPD) in preterm infants is predominantly inherited. The purpose of this review is to discuss current published genetic association studies in light of the accumulated knowledge in genomics. RECENT
findingsMajor advances in the development of next-generation genotyping and sequencing platforms, statistical methodologies, inventories of functional outcome of some common genetic polymorphisms and large-scale cataloguing of genetic variability among many of the world's ethnic populations have greatly facilitated the study of polygenic conditions. For BPD, genetic-association studies have primarily focused on components of innate (e.g. first-line) immune and antioxidant defences, mechanisms of vascular and lung remodelling, and surfactant proteins. However, studies have been limited in sample size and therefore fraught with a high probability of false-positive and false-negative associations. Nonetheless, candidate gene associations have indicated some novel biological pathways and provide a conceptual framework for the design of larger, collaborative population-based studies. SUMMARY: Although studies to date have not been able to identify reproducible genetic risk markers for BPD, they have directed us towards new, promising research avenues.
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