ArticleThe American journal of surgical pathology2010
Use of fluorescence in situ hybridization (FISH) to distinguish intranodal nevus from metastatic melanoma.
Article in The American journal of surgical pathology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 91 citations in OpenAlex.
- FluorescenceExperimental and therapeutic medicine · 2025Article
- Through the looking glass and what you find there: making sense of comparative genomic hybridization and fluorescence in situ hybridization for melanoma diagnosis.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2020Review
- Four-color fluorescence in-situ hybridization is useful to assist to distinguish early stage acral and cutaneous melanomas from dysplastic junctional or compound nevus.Diagnostic pathology · 2020Article
- Comparison of melanoma gene expression score with histopathology, fluorescence in situ hybridization, and SNP array for the classification of melanocytic neoplasms.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2018Article
- Review of diagnostic, prognostic, and predictive biomarkers in melanoma.Clinical & experimental metastasis · 2018Review
- Novel computational method for predicting polytherapy switching strategies to overcome tumor heterogeneity and evolution.Scientific reports · 2017Article
- Comparison between melanoma gene expression score and fluorescence in situ hybridization for the classification of melanocytic lesions.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2016Article
- From melanocytes to melanomas.Nature reviews. Cancer · 2016Review
- 5-Hydroxymethylcytosine expression in metastatic melanoma versus nodal nevus in sentinel lymph node biopsies.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2015Article
- Diagnostic and prognostic biomarkers in melanoma.The Journal of clinical and aesthetic dermatology · 2014Review
- Assessment of copy number status of chromosomes 6 and 11 by FISH provides independent prognostic information in primary melanoma.The American journal of surgical pathology · 2011Article
- Correlating array comparative genomic hybridization findings with histology and outcome in spitzoid melanocytic neoplasms.International journal of clinical and experimental pathology · 2010Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
With the increase in sentinel lymph node biopsies in melanoma patients, pathologists are frequently confronted with small deposits of morphologically bland melanocytes in the node, which occasionally cannot be readily classified as benign nodal nevi or melanoma. As most melanomas harbor characteristic chromosomal aberrations which can be used to distinguish them from benign nevi, we used fluorescence in-situ hybridization (FISH) with markers for 3 regions on chromosome 6 and 1 on chromosome 11 to determine the presence of chromosomal aberrations in sentinel lymph node specimens with small foci of melanocytes that had been diagnosed as metastatic melanoma or nodal nevi by histopathology. Fifty-nine tissue samples from 41 patients (24 lymph node metastases, 17 with nodal nevi, and 18 of the available corresponding primary melanomas) were analyzed by FISH. Twenty of 24 (83%) cases diagnosed as metastatic melanoma showed aberrations by FISH. Of the 4 negative cases, 3 were unequivocal melanoma metastases, whereas 1 on re-review was histopathologically equivocal. Of the 17 nodal nevi, 1 (6%) also showed aberrations by FISH, whereas the remainder was negative. Multiple aberrations were present in the positive case, some of which were also found in the corresponding primary tumor, suggesting that this case represents a deceptively bland melanoma metastasis that had been misclassified by histomorphology. Our data indicate that FISH is a useful adjunct tool to traditional methods in the diagnostic workup of deposits of melanocytes in lymph nodes that are histopathologically ambiguous.
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