ArticleThe Journal of biological chemistry2010
Podocyte injury induces nuclear translocation of WTIP via microtubule-dependent transport.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Cytoskeleton-associated protein 4 affects podocyte cytoskeleton dynamics in diabetic kidney disease.JCI insight · 2025Article
- Article
- Essential role of Wtip in mouse development and maintenance of the glomerular filtration barrier.American journal of physiology. Renal physiology · 2022Article
- GAP-43 ameliorates Podocyte injury by decreasing nuclear NFATc1 expression.Biochemistry and biophysics reports · 2021Article
- The Ajuba family protein Wtip regulates actomyosin contractility during vertebrate neural tube closure.Journal of cell science · 2018Article
- A small molecule screening to detect potential therapeutic targets in human podocytes.American journal of physiology. Renal physiology · 2017Article
- Nephrin Suppresses Hippo Signaling through the Adaptor Proteins Nck and WTIP.The Journal of biological chemistry · 2016Article
- Podocytes … What's Under Yours? (Podocytes and Foot Processes and How They Change in Nephropathy).Frontiers in endocrinology · 2015Review
- Nuclear import of β-dystroglycan is facilitated by ezrin-mediated cytoskeleton reorganization.PloS one · 2014Article
- Role of Rac1-mineralocorticoid-receptor signalling in renal and cardiac disease.Nature reviews. Nephrology · 2013Review
- Wtip- and gadd45a-interacting protein dendrin is not crucial for the development or maintenance of the glomerular filtration barrier.PloS one · 2013Article
- Signaling from the podocyte intercellular junction to the actin cytoskeleton.Seminars in nephrology · 2012Review
- Current concepts of the podocyte in nephrotic syndrome.Kidney research and clinical practice · 2012Review
- WT1-interacting protein (Wtip) regulates podocyte phenotype by cell-cell and cell-matrix contact reorganization.American journal of physiology. Renal physiology · 2012Article
- TM4SF10 and ADAP interaction in podocytes: role in Fyn activity and nephrin phosphorylation.American journal of physiology. Cell physiology · 2011Article
- APOL1 localization in normal kidney and nondiabetic kidney disease.Journal of the American Society of Nephrology : JASN · 2011Article
- The podocyte cytoskeleton--key to a functioning glomerulus in health and disease.Nature reviews. Nephrology · 2011Review
- PINCH1 is transcriptional regulator in podocytes that interacts with WT1 and represses podocalyxin expression.PloS one · 2011Article
- Out on a LIM: chronic kidney disease, podocyte phenotype and the Wilm's tumor interacting protein (WTIP).Transactions of the American Clinical and Climatological Association · 2011Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Podocyte structural and transcriptional phenotype plasticity characterizes glomerular injury. Transcriptional activity of WT1 (Wilm's tumor 1) is required for normal podocyte structure and is repressed by the podocyte adherens junction protein, WTIP (WT1 interacting protein). Here we show that WTIP translocated into podocyte nuclei in lipopolysaccharide (LPS)-treated mice, a model of transient nephrotic syndrome. Cultured podocytes, which stably expressed an epitope-tagged WTIP, were treated with LPS. Imaging and cellular fractionation studies demonstrated that WTIP translocated from podocyte cell contacts into nuclei within 6 h and relocalized to cell contacts within 24 h after LPS treatment. LPS-stimulated WTIP nuclear translocation required JNK activity, which assembled a multiprotein complex of the scaffolding protein JNK-interacting protein 3 and the molecular motor dynein. Intact microtubule networks and dynein activity were necessary for LPS-stimulated WTIP translocation. Podocytes expressing sh-Wtip change morphology and demonstrate altered actin assembly in cell spreading assays. Stress signaling pathways initiate WTIP nuclear translocation, and the concomitant loss of WTIP from cell contacts changes podocyte morphology and dynamic actin assembly, suggesting a mechanism that transmits changes in podocyte morphology to the nucleus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.