ArticleBiophysical journal2010
Bilayer edges catalyze supported lipid bilayer formation.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 71 citations in OpenAlex.
- Incorporation of transmembrane protein antigens into phospholipid bilayers supported on silica microbeads using membrane fusion with budded virions of recombinant baculovirus.Biotechnology letters · 2025Article
- Direct detection of deformation modes on varying length scales in active biopolymer networks.bioRxiv : the preprint server for biology · 2025Article
- Atherosclerotic Oxidized Lipids Affect Formation and Biophysical Properties of Supported Lipid Bilayers and Simulated Membranes.The journal of physical chemistry. B · 2024Article
- Microelectrode Arrays Measure Blocking of Voltage-Gated Calcium Ion Channels on Supported Lipid Bilayers Derived from Primary Neurons.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Bioelectrochemical platforms to study and detect emerging pathogens.MRS bulletin · 2021Review
- Supported Planar Single and Multiple Bilayer Formation by DOPC Vesicle Rupture on Mica Substrate: A Mechanism as Revealed by Atomic Force Microscopy Study.The Journal of membrane biology · 2020Article
- Surface Plasmon Resonance Study of the Binding of PEO-PPO-PEO Triblock Copolymer and PEO Homopolymer to Supported Lipid Bilayers.Langmuir : the ACS journal of surfaces and colloids · 2018Article
- Filament rigidity and connectivity tune the deformation modes of active biopolymer networks.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Liquid behavior of cross-linked actin bundles.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Characterization of PAH/DPPG layer-by-layer films by VUV spectroscopy.The European physical journal. E, Soft matter · 2013Article
- Sialylneolacto-N-tetraose c (LSTc)-bearing liposomal decoys capture influenza A virus.The Journal of biological chemistry · 2013Article
- The role of lateral tension in calcium-induced DPPS vesicle rupture.Langmuir : the ACS journal of surfaces and colloids · 2012Article
- Hemifusion of giant unilamellar vesicles with planar hydrophobic surfaces: a fluorescence microscopy study.Soft matter · 2012Article
- Cholesterol-dependent nanomechanical stability of phase-segregated multicomponent lipid bilayers.Biophysical journal · 2010Article
- Supported bilayers with excess membrane reservoir: a template for reconstituting membrane budding and fission.Biophysical journal · 2010Article
- Studies of bilayers and vesicle adsorption to solid substrates: development of a miniature streaming potential apparatus (SPA).Langmuir : the ACS journal of surfaces and colloids · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Supported lipid bilayers (SLB) are important for the study of membrane-based phenomena and as coatings for biosensors. Nevertheless, there is a fundamental lack of understanding of the process by which they form from vesicles in solution. We report insights into the mechanism of SLB formation by vesicle adsorption using temperature-controlled time-resolved fluorescence microscopy at low vesicle concentrations. First, lipid accumulates on the surface at a constant rate up to approximately 0.8 of SLB coverage. Then, as patches of SLB nucleate and spread, the rate of accumulation increases. At a coverage of approximately 1.5 x SLB, excess vesicles desorb as SLB patches rapidly coalesce into a continuous SLB. Variable surface fluorescence immediately before SLB patch formation argues against the existence of a critical vesicle density necessary for rupture. The accelerating rate of accumulation and the widespread, abrupt loss of vesicles coincide with the emergence and disappearance of patch edges. We conclude that SLB edges enhance vesicle adhesion to the surface and induce vesicle rupture, thus playing a key role in the formation of continuous SLB.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.