ArticleBiophysical journal2010
Modeling multivalent ligand-receptor interactions with steric constraints on configurations of cell-surface receptor aggregates.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- IgE Occupancy and Antigen Valency Cooperate to Control FcεRI Aggregation Geometry and Signaling Efficiency.International journal of molecular sciences · 2026Article
- IgE occupancy and antigen valency cooperate to control FcεRI aggregation geometry and signaling efficiency.bioRxiv : the preprint server for biology · 2025Article
- Hapten-Decorated DNA Nanostructures Decipher the Antigen-Mediated Spatial Organization of Antibodies Involved in Mast Cell Activation.ACS nano · 2023Article
- Article
- A spatio-temporal model reveals self-limiting FcRoyal Society open science · 2018Article
- Rule-based modelling provides an extendable framework for comparing candidate mechanisms underpinning clathrin polymerisation.Scientific reports · 2018Article
- Maximal aggregation of polynomial dynamical systems.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Sugars Require Rigid Multivalent Displays for Activation of Mouse Sperm Acrosomal Exocytosis.Biochemistry · 2017Article
- Quantitative computational models of molecular self-assembly in systems biology.Physical biology · 2017Review
- A general model for predicting the binding affinity of reversibly and irreversibly dimerized ligands.PloS one · 2017Article
- Glycopolymer induction of mouse sperm acrosomal exocytosis shows highly cooperative self-antagonism.Biochemical and biophysical research communications · 2016Article
- BioNetFit: a fitting tool compatible with BioNetGen, NFsim and distributed computing environments.Bioinformatics (Oxford, England) · 2016Article
- Modeling for (physical) biologists: an introduction to the rule-based approach.Physical biology · 2015Review
- Optimal aggregation of FcεRI with a structurally defined trivalent ligand overrides negative regulation driven by phosphatases.ACS chemical biology · 2014Article
- Exact hybrid particle/population simulation of rule-based models of biochemical systems.PLoS computational biology · 2014Article
- An Interaction Library for the FcεRI Signaling Network.Frontiers in immunology · 2014Review
- Pleomorphic ensembles: formation of large clusters composed of weakly interacting multivalent molecules.Biophysical journal · 2013Article
- Article
- Guidelines for visualizing and annotating rule-based models.Molecular bioSystems · 2011Article
- The efficiency of reactant site sampling in network-free simulation of rule-based models for biochemical systems.Physical biology · 2011Article
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 1 country.
Funding
Abstract
We use flow cytometry to characterize equilibrium binding of a fluorophore-labeled trivalent model antigen to bivalent IgE-FcepsilonRI complexes on RBL cells. We find that flow cytometric measurements are consistent with an equilibrium model for ligand-receptor binding in which binding sites are assumed to be equivalent and ligand-induced receptor aggregates are assumed to be acyclic. However, this model predicts extensive receptor aggregation at antigen concentrations that yield strong cellular secretory responses, which is inconsistent with the expectation that large receptor aggregates should inhibit such responses. To investigate possible explanations for this discrepancy, we evaluate four rule-based models for interaction of a trivalent ligand with a bivalent cell-surface receptor that relax simplifying assumptions of the equilibrium model. These models are simulated using a rule-based kinetic Monte Carlo approach to investigate the kinetics of ligand-induced receptor aggregation and to study how the kinetics and equilibria of ligand-receptor interaction are affected by steric constraints on receptor aggregate configurations and by the formation of cyclic receptor aggregates. The results suggest that formation of linear chains of cyclic receptor dimers may be important for generating secretory signals. Steric effects that limit receptor aggregation and transient formation of small receptor aggregates may also be important.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.