ArticleAmerican journal of human genetics2010
Highly punctuated patterns of population structure on the X chromosome and implications for African evolutionary history.
Article in American journal of human genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Common X-Chromosome Variants Are Associated with Parkinson Disease Risk.Annals of neurology · 2021Pooled it
- Inferring the Relative Contributions of Evolutionary Processes Shaping X Chromosome Dynamics in the Common Marmoset (Callithrix jacchus) in the Presence of Twinning and Hematopoietic Chimerism.Genome biology and evolution · 2026Article
- No evidence that ACE2 or TMPRSS2 drive population disparity in COVID risks.BMC medicine · 2024Article
- The fire ant social chromosome supergene variant Sb shows low diversity but high divergence from SB.Molecular ecology · 2017Article
- The Relative Contributions of theGenetics · 2017Article
- IBD Sharing between Africans, Neandertals, and Denisovans.Genome biology and evolution · 2016Article
- Beyond 2/3 and 1/3: The Complex Signatures of Sex-Biased Admixture on the X Chromosome.Genetics · 2015Article
- Article
- Contrasting X-linked and autosomal diversity across 14 human populations.American journal of human genetics · 2014Article
- Article
- HMOX1 gene promoter alleles and high HO-1 levels are associated with severe malaria in Gambian children.PLoS pathogens · 2012Article
- Estimators of the human effective sex ratio detect sex biases on different timescales.American journal of human genetics · 2010Article
- Article
- Genetic structure in African populations: implications for human demographic history.Cold Spring Harbor symposia on quantitative biology · 2009Review
- XWAS: A Software Toolset for Genetic Data Analysis and Association Studies of the X Chromosome.The Journal of heredityArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
It is well known that average levels of population structure are higher on the X chromosome compared to autosomes in humans. However, there have been surprisingly few analyses on the spatial distribution of population structure along the X chromosome. With publicly available data from the HapMap Project and Perlegen Sciences, we show a strikingly punctuated pattern of X chromosome population structure. Specifically, 87% of X-linked HapMap SNPs within the top 1% of F(ST) values cluster into five distinct loci. The largest of these regions spans 5.4 Mb and contains 66% of the most highly differentiated HapMap SNPs on the X chromosome. We demonstrate that the extreme clustering of highly differentiated SNPs on the X chromosome is not an artifact of ascertainment bias, nor is it specific to the populations genotyped in the HapMap Project. Rather, additional analyses and resequencing data suggest that these five regions have been substrates of recent and strong adaptive evolution. Finally, we discuss the implications that patterns of X-linked population structure have on the evolutionary history of African populations.
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