ArticleBMC medical genetics2010
Impact of gene variants on sex-specific regulation of human Scavenger receptor class B type 1 (SR-BI) expression in liver and association with lipid levels in a population-based study.
Article in BMC medical genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Different Functions of Human Scavenger Receptors BI and BII Overexpressed in a Murine Abdominal Sepsis Model.Biomolecules · 2026Article
- In the Beginning, Lipoproteins Cross the Endothelial Barrier.Journal of atherosclerosis and thrombosis · 2024Review
- Interaction betweenNutrients · 2023Article
- High Density Lipoproteins: Is There a Comeback as a Therapeutic Target?Handbook of experimental pharmacology · 2022Article
- SR-B1, a Key Receptor Involved in the Progression of Cardiovascular Disease: A Perspective from Mice and Human Genetic Studies.Biomedicines · 2021Review
- Sex-Specific Influence of the SCARB1 Rs5888 SNP on the Serum Lipid Response to Atorvastatin in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention.Pharmacogenomics and personalized medicine · 2020Article
- Meta-analysis of the association between SCARB1 polymorphism and fasting blood lipid levels.Oncotarget · 2017Article
- Human SR-BI and SR-BII Potentiate Lipopolysaccharide-Induced Inflammation and Acute Liver and Kidney Injury in Mice.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Genetic contribution of SCARB1 variants to lipid traits in African Blacks: a candidate gene association study.BMC medical genetics · 2015Article
- Age- and gender-dependent heterogeneous proportion of variation explained by SNPs in quantitative traits reflecting human health.Age (Dordrecht, Netherlands) · 2015Article
- Investigation of genetic variation in scavenger receptor class B, member 1 (SCARB1) and association with serum carotenoids.Ophthalmology · 2013Article
- A coding variant in SR-BI (I179N) significantly increases atherosclerosis in mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2013Article
- Functional genomics of the human high-density lipoprotein receptor scavenger receptor BI: an old dog with new tricks.Current opinion in endocrinology, diabetes, and obesity · 2013Review
- SCARB1 single nucleotide polymorphism (rs5888) is associated with serum lipid profile and myocardial infarction in an age- and gender-dependent manner.Lipids in health and disease · 2013Article
- Gender and single nucleotide polymorphisms in MTHFR, BHMT, SPTLC1, CRBP2, CETP, and SCARB1 are significant predictors of plasma homocysteine normalized by RBC folate in healthy adults.The Journal of nutrition · 2012Article
- The Alzheimer's associated 5' region of the SORL1 gene cis regulates SORL1 transcripts expression.Neurobiology of aging · 2012Article
- Scavenger receptor class B member 1 protein: hepatic regulation and its effects on lipids, reverse cholesterol transport, and atherosclerosis.Hepatic medicine : evidence and research · 2011Review
- Cholesterol as a potential target for castration-resistant prostate cancer.Pharmaceutical research · 2011Review
- A case-control analysis of common variants in GIP with type 2 diabetes and related biochemical parameters in a South Indian population.BMC medical genetics · 2010Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundSeveral studies have noted that genetic variants of SCARB1, a lipoprotein receptor involved in reverse cholesterol transport, are associated with serum lipid levels in a sex-dependent fashion. However, the mechanism underlying this gene by sex interaction has not been explored.
methodsWe utilized both epidemiological and molecular methods to study how estrogen and gene variants interact to influence SCARB1 expression and lipid levels. Interaction between 35 SCARB1 haplotype-tagged polymorphisms and endogenous estradiol levels was assessed in 498 postmenopausal Caucasian women from the population-based Rancho Bernardo Study. We further examined associated variants with overall and SCARB1 splice variant (SR-BI and SR-BII) expression in 91 human liver tissues using quantitative real-time PCR.
resultsSeveral variants on a haplotype block spanning intron 11 to intron 12 of SCARB1 showed significant gene by estradiol interaction affecting serum lipid levels, the strongest for rs838895 with HDL-cholesterol (p=9.2x10(-4)) and triglycerides (p=1.3x10(-3)) and the triglyceride:HDL cholesterol ratio (p=2.7x10(-4)). These same variants were associated with expression of the SR-BI isoform in a sex-specific fashion, with the strongest association found among liver tissue from 52 young women<45 years old (p=0.002).
conclusionsEstrogen and SCARB1 genotype may act synergistically to regulate expression of SCARB1 isoforms and impact serum levels of HDL cholesterol and triglycerides. This work highlights the importance of considering sex-dependent effects of gene variants on serum lipid levels.
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