ArticleBMC medical research methodology2010
Design, recruitment, and retention of African-American smokers in a pharmacokinetic study.
Article in BMC medical research methodology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Reaching the hard-to-reach: a systematic review of strategies for improving health and medical research with socially disadvantaged groups.BMC medical research methodology · 2014Pooled it
- Factors influencing enrollment of African Americans in the Look AHEAD trial.Clinical trials (London, England) · 2012Trial
- Proactive and Reactive Recruitment of Black and Latino Adolescents in a Vaping Prevention Randomized Controlled Trial.Children (Basel, Switzerland) · 2022Article
- Is the implementation of smoke-free policies at workplaces associated with living in a smoke-free home?: Findings from a national population-based study in Malaysia.Tobacco induced diseases · 2019Article
- Technology-based interventions for weight management: current randomized controlled trial evidence and future directions.Journal of behavioral medicine · 2017Review
- Characterizing researchers by strategies used for retaining minority participants: results of a national survey.Contemporary clinical trials · 2013Article
- Moderating effects of race in clinical trial participation and outcomes among marijuana-dependent young adults.Drug and alcohol dependence · 2012Article
- Effects of menthol on the pharmacokinetics of bupropion among Black smokers.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2012Article
- Effect of a primary health-care-based controlled trial for cardiorespiratory fitness in refugee women.BMC family practice · 2010Article
- Optimizing Clinical Trial Enrollment Methods Through "Goal Programming"Applied clinical trialsArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundAfrican-Americans remain underrepresented in clinical research despite experiencing a higher burden of disease compared to all other ethnic groups in the United States. The purpose of this article is to describe the study design and discuss strategies used to recruit and retain African-American smokers in a pharmacokinetic study.
methodsThe parent study was designed to evaluate the differences in the steady-state concentrations of bupropion and its three principal metabolites between African-American menthol and non-menthol cigarette smokers. Study participation consisted of four visits at a General Clinical Research Center (GCRC) over six weeks. After meeting telephone eligibility requirements, phone-eligible participants underwent additional screening during the first two GCRC visits. The last two visits (pharmacokinetic study phase) required repeated blood draws using an intravenous catheter over the course of 12 hours.
resultsFive hundred and fifteen African-American smokers completed telephone screening; 187 were phone-eligible and 92 were scheduled for the first GCRC visit. Of the 81 who attended the first visit, 48 individuals were enrolled in the pharmacokinetic study, and a total of 40 individuals completed the study (83% retention rate).
conclusionsAlthough recruitment of African-American smokers into a non-treatment, pharmacokinetic study poses challenges, retention is feasible. The results provide valuable information for investigators embarking on non-treatment laboratory-based studies among minority populations.
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