Evidence map›Paper›PMID 20085628›Full record

Trial reportCritical care (London, England)2010

Effects of a fish oil containing lipid emulsion on plasma phospholipid fatty acids, inflammatory markers, and clinical outcomes in septic patients: a randomized, controlled clinical trial.

Vera M Barbosa, Elizabeth A Miles, Conceição Calhau, Estevão Lafuente, Philip C Calder

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Critical care (London, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04572373 (Supplements SMOF in TPN for Liver Transplantation Recipients), which is not on this map. Cited by 58 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 14 pooled it
14.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04572373 completednot on this mapstarted 2012, after this paper: background citation

Supplements SMOF in TPN for Liver Transplantation Recipients

TypeobservationalSponsorChang Gung Memorial HospitalRan2012 to 2015Enrolled54ConditionsLiver Transplantation, Total Parenteral Nutrition, End-stage Liver DiseaseArmsSMOFlipid
3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 14 syntheses or guidelines pooled it, 176 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Vera M BarbosaInstitute of Human Nutrition, School of Medicine, University of Southampton, IDS Building, MP887 Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK. barbosa.vera@gmail.com
Elizabeth A Miles
Conceição Calhau
Estevão Lafuente
Philip C Calder
University of Southampton · GBHospital Padre Américo · PTSouthampton General Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe effect of parenteral fish oil in septic patients is not widely studied. This study investigated the effects of parenteral fish oil on plasma phospholipid fatty acids, inflammatory mediators, and clinical outcomes.

methodsTwenty-five patients with systemic inflammatory response syndrome or sepsis, and predicted to need parenteral nutrition were randomized to receive either a 50:50 mixture of medium-chain fatty acids and soybean oil or a 50:40:10 mixture of medium-chain fatty acids, soybean oil and fish oil. Parenteral nutrition was administrated continuously for five days from admission. Cytokines and eicosanoids were measured in plasma and in lipopolysaccharide-stimulated whole blood culture supernatants. Fatty acids were measured in plasma phosphatidylcholine.

resultsFish oil increased eicosapentaenoic acid in plasma phosphatidylcholine (P < 0.001). Plasma interleukin (IL)-6 concentration decreased significantly more, and IL-10 significantly less, in the fish oil group (both P < 0.001). At Day 6 the ratio PO2/FiO2 was significantly higher in the fish oil group (P = 0.047) and there were fewer patients with PO2/FiO2 <200 and <300 in the fish oil group (P = 0.001 and P = 0.015, respectively). Days of ventilation, length of intensive care unit (ICU) stay and mortality were not different between the two groups. The fish oil group tended to have a shorter length of hospital stay (22 +/- 7 vs. 55 +/- 16 days; P = 0.079) which became significant (28 +/- 9 vs. 82 +/- 19 days; P = 0.044) when only surviving patients were included.

conclusionsInclusion of fish oil in parenteral nutrition provided to septic ICU patients increases plasma eicosapentaenoic acid, modifies inflammatory cytokine concentrations and improves gas exchange. These changes are associated with a tendency towards shorter length of hospital stay. TRIALS REGISTRATION: Clinical Trials Registration Number ISRCTN89432944.

Indexed as

AgedAged, 80 and overEmulsionsFatty Acids, Omega-3FemaleFish OilsHumansInflammation MediatorsLength of StayMaleMiddle AgedPhospholipidsSepsisSingle-Blind MethodSoybean OilTreatment OutcomeEmulsionsFatty Acids, Omega-3Fish OilsInflammation MediatorsPhospholipidsSoybean Oil

Identifiers

PMID20085628
PMCPMC2875515
OpenAlexW2118704546

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.